Evidence map›Paper›PMID 35744768›Full record

ArticleMicroorganisms2022

mRNA BNT162b Vaccine Elicited Higher Antibody and CD4

Federica Zavaglio, Irene Cassaniti, Josè Camilla Sammartino, Stelvio Tonello, Pier Paolo Sainaghi, Viola Novelli, Federica Meloni, Daniele Lilleri, Fausto Baldanti

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Federica ZavaglioMicrobiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.ORCID 0000-0001-5471-1711
Irene CassanitiMicrobiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.ORCID 0000-0002-3385-2088
Josè Camilla SammartinoMicrobiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.ORCID 0000-0003-3707-3118
Stelvio TonelloImmunoreumatology Laboratory, Center for Translational Research on Autoimmune and Allergic Disease-CAAD, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0002-0836-0890
Pier Paolo SainaghiImmunoreumatology Laboratory, Center for Translational Research on Autoimmune and Allergic Disease-CAAD, University of Piemonte Orientale, 28100 Novara, Italy.ORCID 0000-0001-8322-9158
Viola NovelliMedical Direction, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.ORCID 0000-0002-3341-2533
Federica MeloniResearch Laboratory of Lung Diseases, Section of Cell Biology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
Daniele LilleriMicrobiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.ORCID 0000-0001-7747-7622
Fausto BaldantiMicrobiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.
Policlinico San Matteo Fondazione · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Pavia · IT

Funding

Fondazione Cariplo 2020- 1374Ministero della Salute 2020-12,371,760
6 · The paper itself

Abstract

We compared the development and persistence of antibody and T-cell responses elicited by the mRNA BNT162b2 vaccine or SARS-CoV-2 infection. We analysed 37 post-COVID-19 patients (15 with pneumonia and 22 with mild symptoms) and 20 vaccinated subjects. Anti-Spike IgG and neutralising antibodies were higher in vaccinated subjects and in patients with pneumonia than in patients with mild COVID-19, and persisted at higher levels in patients with pneumonia while declining in vaccinated subjects. However, the booster dose restored the initial antibody levels. The proliferative CD4

Indexed as

antibody responsecytokine productionmRNA BNT162b vaccineSARS-CoV-2T-cell response

Identifiers

PMID35744768
PMCPMC9228401
OpenAlexW4283122559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.