Evidence map›Paper›PMID 35744609›Full record

ArticleMicroorganisms2022

An In Silico Analysis of Malaria Pre-Erythrocytic-Stage Antigens Interpreting Worldwide Genetic Data to Suggest Vaccine Candidate Variants and Epitopes.

Amed Ouattara, Ankit Dwivedi, Matthew Adams, Amadou Niangaly, Matthew B Laurens, Myaing M Nyunt, Christopher V Plowe, Abdoulaye Djimde, Shannon Takala-Harrison, Joana C Silva

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. IdentifyingResearch square · 2024
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Amed OuattaraMalaria Research Program, Center for Vaccine Development and Global Heath, School of Medicine, University of Maryland School of Medicine, 685 West Baltimore St., Baltimore, MD 21201, USA.ORCID 0000-0003-1964-7130
Ankit DwivediInstitute for Genome Sciences, University of Maryland School of Medicine, 670 West Baltimore St., Baltimore, MD 21201, USA.ORCID 0000-0001-7294-1975
Matthew AdamsMalaria Research Program, Center for Vaccine Development and Global Heath, School of Medicine, University of Maryland School of Medicine, 685 West Baltimore St., Baltimore, MD 21201, USA.
Amadou NiangalyMalaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako P.O. Box 1805, Mali.
Matthew B LaurensMalaria Research Program, Center for Vaccine Development and Global Heath, School of Medicine, University of Maryland School of Medicine, 685 West Baltimore St., Baltimore, MD 21201, USA.
Myaing M NyuntMalaria Research Program, Center for Vaccine Development and Global Heath, School of Medicine, University of Maryland School of Medicine, 685 West Baltimore St., Baltimore, MD 21201, USA.
Christopher V PloweMalaria Research Program, Center for Vaccine Development and Global Heath, School of Medicine, University of Maryland School of Medicine, 685 West Baltimore St., Baltimore, MD 21201, USA.
Abdoulaye DjimdeMalaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako P.O. Box 1805, Mali.ORCID 0000-0003-0062-2283
Shannon Takala-HarrisonMalaria Research Program, Center for Vaccine Development and Global Heath, School of Medicine, University of Maryland School of Medicine, 685 West Baltimore St., Baltimore, MD 21201, USA.
Joana C SilvaInstitute for Genome Sciences, University of Maryland School of Medicine, 670 West Baltimore St., Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USUniversité des Sciences, des Techniques et des Technologies de Bamako · ML

Funding

Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DUNNING HOTOPP, JULIE · 2014 to 2023
$36.5M
Genome-wide sieve analysis and immunological validation to identify targets of protective efficacy in field trials of a whole-organism malaria vaccineR01AI141900 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CARNEIRO DA SILVA, JOANA · 2019 to 2023
$3.9M
Safety and efficacy of PfSPZ malaria vaccine in malaria-exposed adultsU01AI112367 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LAURENS, MATTHEW BRENT · 2015 to 2018
$2.8M
Identification and validation of molecular markers of piperaquine resistanceR01AI125579 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI HARRISON, SHANNON TAKALA · 2017 to 2021
$1.6M
Designing a diversity-covering multiantigen multi-strain vaccineK01HL140285 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI OUATTARA, AMED · 2019 to 2023
$712k
NHLBI NIH HHS K01 HL140285NIAID NIH HHS HHSN272201300022CNIAID NIH HHS HHSN272201300022INIAID NIH HHS R01 AI125579NIAID NIH HHS R01 AI141900NIAID NIH HHS U01 AI112367NIAID NIH HHS U19 AI110820NIH HHS 1K01HL140285-01A1, NIH HHSN272201300022I, NIH U01AI112367, NHMRC GNT1161066, U19 AI110820.R01 AI141900
6 · The paper itself

Abstract

Failure to account for genetic diversity of antigens during vaccine design may lead to vaccine escape. To evaluate the vaccine escape potential of antigens used in vaccines currently in development or clinical testing, we surveyed the genetic diversity, measured population differentiation, and performed in silico prediction and analysis of T-cell epitopes of ten such

Indexed as

antigenglobal diversityliver-stagemultivalent vaccineplasmodiumpolymorphismvariants

Identifiers

PMID35744609
PMCPMC9231253
OpenAlexW4281479996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.