Evidence map›Paper›PMID 35744255›Full record

ArticleMaterials (Basel, Switzerland)2022

Synthesis, Structure-Property Evaluation and Biological Assessment of Supramolecular Assemblies of Bioactive Glass with Glycyrrhizic Acid and Its Monoammonium Salt.

Alimjon D Matchanov, Rakhmat S Esanov, Tobias Renkawitz, Azamjon B Soliev, Elke Kunisch, Isabel Gonzalo de Juan, Fabian Westhauser, Dilshat U Tulyaganov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Alimjon D MatchanovInstitute of bioorganic Chemistry, Mirzo Ulugbek, 83, Tashkent 100170, Uzbekistan.
Rakhmat S EsanovInstitute of bioorganic Chemistry, Mirzo Ulugbek, 83, Tashkent 100170, Uzbekistan.
Tobias RenkawitzDepartment of Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118 Heidelberg, Germany.
Azamjon B SolievDepartment of Natural-Mathematical Sciences, Turin Polytechnic University in Tashkent, 17, Small Ring Street, Tashkent 100095, Uzbekistan.
Elke KunischDepartment of Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118 Heidelberg, Germany.
Isabel Gonzalo de JuanDisperse Solid Materials, Technical University Darmstadt, Otto-Berndt-Straße 3, 64287 Darmstadt, Germany.
Fabian WesthauserDepartment of Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstraße 200a, 69118 Heidelberg, Germany.ORCID 0000-0001-9948-4209
Dilshat U TulyaganovDepartment of Natural-Mathematical Sciences, Turin Polytechnic University in Tashkent, 17, Small Ring Street, Tashkent 100095, Uzbekistan.ORCID 0000-0003-3540-7532
Heidelberg University · DETurin Polytechnic University · UZNational University of Uzbekistan · UZTechnische Universität Darmstadt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medical nutrients obtained from plants have been used in traditional medicine since ancient times, owning to the protective and therapeutic properties of plant extracts and products. Glycyrrhizic acid is one of those that, apart from its therapeutic effect, may contribute to stronger bones, inhibiting bone resorption and improving the bone structure and biomechanical strength. In the present study, we investigated the effect of a bioactive glass (BG) addition to the structure-property relationships of supramolecular assemblies formed by glycyrrhizic acid (GA) and its monoammonium salt (MSGA). FTIR spectra of supramolecular assemblies evidenced an interaction between BG components and hydroxyl groups of MSGA and GA. Moreover, it was revealed that BG components may interact and bond to the carboxyl groups of MSGA. In order to assess their biological effects, BG, MSGA, and their supramolecular assemblies were introduced to a culture of human bone-marrow-derived mesenchymal stromal cells (BMSCs). Both the BG and MSGA had positive influence on BMSC growth, viability, and osteogenic differentiation-these positive effects were most pronounced when BG1d-BG and MSGA were introduced together into cell culture in the form of MSGA:BG assemblies. In conclusion, MSGA:BG assemblies revealed a promising potential as a candidate material intended for application in bone defect reconstruction and bone tissue engineering approaches.

Indexed as

bioactive glassesbone tissue engineeringglycyrrhizic acidsupramolecular assemblies

Identifiers

PMID35744255
PMCPMC9230998
OpenAlexW4282823895

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.