ArticleLife (Basel, Switzerland)2022
Transbronchial Cryobiopsy Compared to Forceps Biopsy for Diagnosis of Acute Cellular Rejection in Lung Transplants: Analysis of 63 Consecutive Procedures.
Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Circulating donor-derived cell-free DNA as a marker for rejection after lung transplantation.Frontiers in immunology · 2023Pooled it
- Bronchoalveolar lavage for supporting acute cellular rejection in lung transplant recipients: A retrospective analysis.JHLT open · 2026Article
- Transbronchial Lung Cryobiopsy and Awake Video-Assisted Thoracic Surgery in Interstitial Lung Disease: Complementary Roles in a Stepwise Diagnostic Approach.Diagnostics (Basel, Switzerland) · 2026Review
- Donor-recipient sex differences: Implications for immunologic outcomes but no impact on survival after lung transplantation.JHLT open · 2026Article
- Exploring acute cellular rejection in lung transplantation: insights from donor-derived cell-free DNA analysis.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2026Article
- Correlation between acute cellular rejection detected with cryobiopsy and elevated dd-cfDNA in lung transplant recipients.JHLT open · 2026Article
- Correlation between acute cellular rejection detected with cryobiopsy and elevated donor-derived cell-free DNA in lung transplant recipients.JHLT open · 2026Article
- Feasibility and Safety of 1.1-mm Cryobiopsy for Acute Rejection Surveillance in Lung Transplant Recipients: A Comparative Study and Review of the Literature.Pulmonary medicine · 2026Observational
- Article
- Transition from Transbronchial Forceps to Cryobiopsy After Lung Transplantation: A Single-Centre Experience.Life (Basel, Switzerland) · 2024Article
- Article
- Efficacy of surveillance bronchoscopyERJ open research · 2024Review
- Article
- Elevated PD-L1 and PECAM-1 as Diagnostic Biomarkers of Acute Rejection in Lung Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Adaptive Immunosuppression in Lung Transplant Recipients Applying Complementary Biomarkers: The Zurich Protocol.Medicina (Kaunas, Lithuania) · 2023Article
- Pulmonary Cryobiopsy in the ICU: Clinical Utility in a Critically Ill Lung Transplant Recipient.Open respiratory archivesArticle
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8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute cellular rejection (ACR) is a complication after lung transplantation (LTx). The diagnosis of ACR is based on histologic findings using transbronchial forceps biopsy (FB). However, its diagnostic accuracy is limited because of the small biopsy size and crush artifacts. Transbronchial cryobiopsy (CB) provides a larger tissue size compared with FB.
methodsFB and CB were obtained consecutively during the same bronchoscopy (February 2020-April 2021). All biopsies were scored according to the ISHLT criteria by three pathologists. Interobserver agreement was scored by the kappa index. We assessed the severity of bleeding and the presence of pneumothorax.
resultsIn total, 35 lung transplant recipients were included, and 126 CBs and 315 FBs were performed in 63 consecutive bronchoscopies. ACR (A1-A3, minimal-moderate) was detected in 18 cases (28.6%) by CB, whereas ACR was detected in 3 cases (4.8%) by FB. Moderate and severe bleeding complicated FB and CB procedures in 23 cases (36.5%) and 1 case (1.6%), respectively. Pneumothorax occurred in 6.3% of patients. The interobserver agreement was comparable for both CB and FB.
conclusionsCB provided an improved diagnostic yield for ACR diagnosis, leading to reclassification and changes in treatment strategies in 28.6% of cases. Prospective studies should better define the role of CB after LTx.
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