Evidence map›Paper›PMID 35743855›Full record

ArticleLife (Basel, Switzerland)2022

Ecdysteroids as Potent Enzyme Inhibitors and Verification of Their Activity Using In Vitro and In Silico Docking Studies.

Nilufar Z Mamadalieva, Hidayat Hussain, Adriano Mollica, Gokhan Zengin, Rano Z Mamadalieva, Sameh S Elhady, Sana A Fadil, Mohamed L Ashour, Fadia S Youssef

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Subcutaneous application ofFrontiers in public health · 2026
    Observational
  2. Review
  3. Chemometric discrimination of eightCurrent research in food science · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 6 countries.

Nilufar Z MamadalievaInstitute of the Chemistry of Plant Substances, Academy Sciences of Uzbekistan, Tashkent 100170, Uzbekistan.ORCID 0000-0003-1756-3638
Hidayat HussainDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120 Halle, Germany.ORCID 0000-0002-8654-8127
Adriano MollicaDepartment of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-7242-4860
Gokhan ZenginDepartment of Biology, Science Faculty, Selcuk University, Konya 42130, Turkey.ORCID 0000-0001-6548-7823
Rano Z MamadalievaKokand State Pedagogical Institute, Turon Str. 23, Kokand 713000, Uzbekistan.
Sameh S ElhadyDepartment of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-3799-0581
Sana A FadilDepartment of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-4986-1904
Mohamed L AshourDepartment of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia.ORCID 0000-0002-9270-6267
Fadia S YoussefDepartment of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.ORCID 0000-0002-5871-2639
Ain Shams University · EGKing Abdulaziz University · SALeibniz Institute of Plant Biochemistry · DEKokand State Pedagogical Institute named after Mukimi · UZSelçuk University · TRUniversity of Chieti-Pescara · IT

Funding

The Deanship of Scientific Research (DSR) at King Abdulaziz University (KAU), Jeddah, Saudi Arabia RG-23-166-43
6 · The paper itself

Abstract

Ecdysteroids represent arthropods' steroidal hormones, and they exist in about 5-6% of plant species. In this study, the enzyme inhibitory activity of 20 ecdysteroids was assessed for the first time via determining their inhibition versus acetylcholinesterase, butyrylcholinesterase, tyrosinase, as well as α-amylase enzymes. Furthermore, 20-Hydroxyecdysone-2,3,22-tri-

Indexed as

ADMETchemometricscholinesterasedrug discoveryecdysteroidshealth caremolecular dockingtyrosinaseα-amylase

Identifiers

PMID35743855
PMCPMC9225039
OpenAlexW4281787929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.