ArticleJournal of personalized medicine2022
Prognostic Significance of Perineural Invasion in Patients with Stage II/III Gastric Cancer Undergoing Radical Surgery.
Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Prognostic Value of Tumor Regression Grade in Geriatric Patients with Locally Advanced Gastric Adenocarcinoma.Medicina (Kaunas, Lithuania) · 2026Article
- Adjuvant Chemotherapy and Chemoradiotherapy in Gastric Cancer: Prognostic Determinants and Real-World Survival Outcomes.Journal of clinical medicine · 2026Article
- Preoperative Diagnostic Value of Spectral CT for Predicting Perineural Invasion in Esophageal Cancer.Cancer medicine · 2025Article
- Article
- Construction of a preoperative nomogram model for predicting perineural invasion in advanced gastric cancer.Frontiers in medicine · 2024Article
- Review
- Implication of perineural invasion in patients with stage II gastric cancer.World journal of surgical oncology · 2023Article
- Article
- Increased Nerve Density Adversely Affects Outcome in Oral Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Article
- Performance of endoscopic submucosal dissection for undifferentiated early gastric cancer: a multicenter retrospective cohort.Endoscopy international open · 2023Article
- Prognostic Factors and the Role of Adjuvant Chemotherapy in Pathological Node-Negative T3 Gastric Cancer.Journal of personalized medicine · 2023Article
- Prognostic Ability of Tumor Budding Outperforms Poorly Differentiated Clusters in Gastric Cancer.Cancers · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The prognostic significance of perineural invasion in patients with gastric cancer (GC) is controversial. This study aimed to determine the prognostic value of perineural invasion in patients with stage II/III GC undergoing radical surgery. A total of 1913 patients with stage II/III GC who underwent curative resection between 1994 and 2015 were recruited. Clinicopathological factors, tumor recurrence patterns, disease-free survival, and cancer-specific survival were compared in terms of perineural invasion. The prognostic factors of disease-free survival and cancer-specific survival were determined using univariate and multivariate analyses. Perineural invasion was found in 57.1% of the patients. Age of <65 years, female sex, large tumor size, upper tumor location, total gastrectomy, advanced tumor invasion depth and nodal involvement, greater metastatic to examined lymph node ratio, undifferentiated tumor, and presence of lymphatic or vascular invasion were significantly associated with perineural invasion. The patients with perineural invasion had higher locoregional/peritoneal recurrence rates than those without. Perineural invasion was independently associated with disease-free survival and cancer-specific survival. In conclusion, perineural invasion positivity is associated with aggressive tumor behaviors and higher locoregional/peritoneal recurrence rates in patients with stage II/III GC undergoing curative surgery. It is an independent unfavorable prognostic factor of disease recurrence and cancer-specific survival.
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