Evidence map›Paper›PMID 35743710›Full record

ReviewJournal of personalized medicine2022

Gender and Autoimmune Liver Diseases: Relevant Aspects in Clinical Practice.

Federica Invernizzi, Marta Cilla, Silvia Trapani, Maria Guarino, Valentina Cossiga, Martina Gambato, Maria Cristina Morelli, Filomena Morisco, Patrizia Burra, Annarosa Floreani and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Sexual dimorphism in the liver.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. A Closer Look into Autoimmune Liver Diseases.International journal of molecular sciences · 2025
    Review
  8. Hepatitis Associated withJournal of clinical medicine · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Sex differences in chronic liver disease and benign liver lesions.JHEP reports : innovation in hepatology · 2023
    Review
  18. Review
  19. Risk Stratification in Primary Biliary Cholangitis.Journal of clinical medicine · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Federica InvernizziCenter for Liver Disease, Division of Internal Medicine and Hepatology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.
Marta CillaCenter for Liver Disease, Division of Internal Medicine and Hepatology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.
Silvia TrapaniItalian National Transplant Center/National Institute of Health, 00162 Rome, Italy.ORCID 0000-0002-8854-7144
Maria GuarinoGastroenterology and Hepatology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80138 Naples, Italy.
Valentina CossigaGastroenterology and Hepatology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80138 Naples, Italy.
Martina GambatoMultivisceral Transplant Unit-Gastroenterology, Department of Surgical Oncological and Gastroenterological Sciences, University Hospital of Padova, 35128 Padova, Italy.ORCID 0000-0002-0101-1938
Maria Cristina MorelliInternal Medicine Unit for the Treatment of Severe Organ Failure, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-9742-1981
Filomena MoriscoGastroenterology and Hepatology Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80138 Naples, Italy.
Patrizia BurraMultivisceral Transplant Unit-Gastroenterology, Department of Surgical Oncological and Gastroenterological Sciences, University Hospital of Padova, 35128 Padova, Italy.ORCID 0000-0002-8791-191X
Annarosa FloreaniIRCCS Negrar, 37024 Verona, Italy.
Special Interest Group Gender in Hepatology of the Italian Association for the Study of the Liver (AISF)
University of Naples Federico II · ITUniversity of Padua · ITIRCCS Ospedale San Raffaele · ITAzienda USL di Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune liver diseases (AILDs) include autoimmune hepatitis, primary biliary cholangitis and primary sclerosing cholangitis. The etiologies of AILD are not well understood but appear to involve a combination of genetic and environmental factors. AILDs commonly affect young individuals and are characterized by a highly variable clinical course. These diseases significantly influence quality of life and can progress toward liver decompensation or the onset of hepatocellular or cholangiocarcinoma; a significant number of patients eventually progress to end-stage liver disease, requiring liver transplantation. In this review, we focus on the sex characteristics and peculiarities of AILD patients and highlight the relevance of a sex-specific analysis in future studies. Understanding the sex differences underlying AILD immune dysregulation may be critical for developing more effective treatments.

Indexed as

autoimmune hepatitis primary biliary cirrhosisautoimmune liver diseasesgenderliver transplantoverlap syndromesprimary sclerosing cholangitis

Identifiers

PMID35743710
PMCPMC9225254
OpenAlexW4281846872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.