Evidence map›Paper›PMID 35743620›Full record

ArticleJournal of clinical medicine2022

Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study.

Anna Waszczuk-Gajda, Olaf Penack, Giulia Sbianchi, Linda Koster, Didier Blaise, Péter Reményi, Nigel Russell, Per Ljungman, Marek Trneny, Jiri Mayer and 30 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 20 institutions in 16 countries.

Anna Waszczuk-GajdaDepartment of Hematology, Transplantation and Internal Medicine, University Clinical Centre-The Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0001-5626-1750
Olaf PenackCharité Universitätsmedizin Berlin, 10771 Berlin, Germany.
Giulia SbianchiTor Vergata University, 00133 Rome, Italy.
Linda KosterEBMT Data Office Leiden, 2333 AA Leiden, The Netherlands.
Didier BlaiseInstitut Paoli Calmettes, 13009 Marseille, France.
Péter ReményiDél-Pesti Centrumkórház, 1097 Budapest, Hungary.
Nigel RussellNottingham University, Nottingham NG7 2QL, UK.
Per LjungmanDepartment of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska Comprehensive Cancer Center, Karolinska University Hospital Huddinge, 17177 Stockholm, Sweden.ORCID 0000-0002-8281-3245
Marek TrnenyUniversity Hospital, 12808 Prague, Czech Republic.ORCID 0000-0002-6952-6073
Jiri MayerUniversity Hospital Brno, 62500 Brno, Czech Republic.
Simona IacobelliTor Vergata University, 00133 Rome, Italy.
Guido KobbeHeinrich Heine Universitaet, 40225 Duesseldorf, Germany.
Christof ScheidUniversity of Cologne, 50923 Cologne, Germany.
Jane ApperleyImperial College, London SW7-2BX, UK.
Cyrille TouzeauCHU Nantes, 44000 Nantes, France.ORCID 0000-0003-0275-2575
Stig LenhoffSkanes University Hospital, 23262 Lund, Sweden.
Esa JantunenDepartment of Medicine, University of Eastern Finland and Hospital District of North Carelia, Kuopio University Hospital, 70211 Kuopio, Finland.
Achilles AnagnostopoulosGeorge Papanicolaou General Hospital, 57010 Thessaloniki, Greece.ORCID 0000-0003-4384-9031
Laura ParisDivision of Hematology, SST Papa Giovanni XXIII, 24127 Bergamo, Italy.ORCID 0000-0002-8248-2343
Paul BrowneHope Directorate, D08 NHY1 Dublin, Ireland.
Catherine ThieblemontHôpital St. Louis, 75010 Paris, France.
Nicolaas SchaapRadboud University Medical Centre, Department of Hematology, 6525 GA Nijmegen, The Netherlands.
Jorge SierraHospital Santa Creu i Sant Pau, 08001 Barcelona, Spain.
Ibrahim Yakoub-AghaCHU de Lille, 59000 Lille, France.ORCID 0000-0003-4524-8782
Laurent GarderetCentre de Recherche Saint-Antoine, Sorbonne Université-INSERM, UMR_S 938, 75013 Paris, France.ORCID 0000-0002-6138-8112
Jan StyczynskiDepartment of Pediatric Hematology and Oncology, Collegium Medicum UMK, 85-067 Bydgoszcz, Poland.ORCID 0000-0002-3158-119X
Helene SchoemansDepartment of Hematology, University Hospitals Leuven, 3000 Leuven, Belgium.
Ivan MoiseevR.M. Gorbacheva Memorial Institute of Hematology, Oncology and Transplantation, Pavlov University, 197022 Saint-Petersburg, Russia.
Rafael F DuarteHospital Universitario Puerta de Hierro Majadahonda-Universidad Autónoma de Madrid, 28222 Madrid, Spain.ORCID 0000-0002-5240-9815
Zinaida PericDepartment of Internal Medicine, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Silvia MontotoDepartment of Haemato-Oncology, St Bartholomew's Hospital, Barts Health NHS Trust, London EC1A 7BE, UK.ORCID 0000-0002-3006-9725
Anja van BiezenEBMT Data Office Leiden, 2333 AA Leiden, The Netherlands.
Malgorzata MikulskaDivision of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genoa, 16121 Genoa, Italy.ORCID 0000-0002-5535-4602
Mahmoud AljurfSection of Adult Haematolgy/BMT, King Faisal Specialist Hospital & Research Centre Oncology, Riyadh 11564, Saudi Arabia.
Tapani RuutuComprehensive Cancer Center, Department of Hematology, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland.
Nicolaus KrögerUniversity Hospital Eppendorf, 20246 Hamburg, Germany.
Curly MorrisBelfast City Hospital, Belfast BT9 7AB, UK.
Christian KoeneckeDepartment of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, 30625 Hannover, Germany.
Stefan SchoenlandDepartment of Internal Medicine V, Division of Hematology/Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0002-4853-5579
Grzegorz W BasakDepartment of Hematology, Transplantation and Internal Medicine, University Clinical Centre-The Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0003-3858-8180
European Society for Blood and Marrow Transplantation · NLMedical University of Warsaw · PLUniversity of Rome Tor Vergata · ITCentre Hospitalier Universitaire de Lille · FRCharité - Universitätsmedizin Berlin · DECollegium Medicum in Bydgoszcz · PLFirst Pavlov State Medical University of St. Petersburg · RUGeneral University Hospital in Prague · CZG. Papanikolaou General Hospital · GRHeidelberg University · DEHeinrich Heine University Düsseldorf · DEHôpital Saint-Louis · FRHospital Universitario Puerta de Hierro Majadahonda · ESImperial College London · GBInserm · FRInstitut Paoli-Calmettes · FRJahn Ferenc Dél-Pesti Kórház és Rendelőintézet · HUKarolinska University Hospital · SEKing Faisal Specialist Hospital & Research Centre · SAKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The main goal of this post hoc analysis of the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study was to evaluate the rate of short- and long-term infectious and non-infectious complications occurring after ASCT in patients with multiple myeloma (MM). Methods: The analysis included all patients with MM from the CALM study who underwent ≥1 ASCT. The primary endpoint of the analysis was to determine the rate of infectious and non-infectious complications after ASCT and to compare them in three time periods: 0−100 days, 101 days−1 year, and >1 year after the first transplant. Results: The analysis included a total of 3552 patients followed up for a median of 56.7 months (range 0.4−108.1). Complication rates decreased with the time from ASCT with 24.85 cases per 100 patient-years from day 0 to 100 days after the transplant, and <2.31 cases per 100 patient-years from the 101st day. At 100 days after ASC T, 45.7% of patients had complications, with infectious events being twice as frequent as non-infectious complications. Bacterial infections (6.5 cases per 100 patient-years, 95% CI: 6.1−7.0) and gastrointestinal complications (4.7 cases per 100 patient-years, 95% CI: 4.3−5.1) were the most common early events. The pattern of complications changed with time from ASCT. The presence of complications after ASCT was not associated with overall survival. Conclusions: Our data provide a solid basis for comparing ASCT-related complications to those caused by emerging treatments in multiple myeloma, such as CAR T-cell therapy and other immunotherapies.

Indexed as

autologous stem cell transplantation in multiple myelomacomplicationsmultiple myeloma

Identifiers

PMID35743620
PMCPMC9225651
OpenAlexW4283219157

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