Evidence map›Paper›PMID 35743501›Full record

ArticleJournal of clinical medicine2022

Comparison of the Hemocompatibility of an Axial and a Centrifugal Left Ventricular Assist Device in an In Vitro Test Circuit.

Patrick Borchers, Patrick Winnersbach, Sandra Kraemer, Christian Beckers, Eva Miriam Buhl, Steffen Leonhardt, Rolf Rossaint, Marian Walter, Thomas Breuer, Christian Bleilevens

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Patrick BorchersMedical Information Technology, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany.
Patrick WinnersbachDepartment of Anesthesiology, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.ORCID 0000-0001-6979-6818
Sandra KraemerDepartment of Intensive Care and Intermediate Care, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.ORCID 0000-0002-2958-843X
Christian BeckersDepartment of Intensive Care and Intermediate Care, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
Eva Miriam BuhlInstitute of Pathology, Electron Microscopy Facility, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.ORCID 0000-0003-0627-9228
Steffen LeonhardtMedical Information Technology, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany.ORCID 0000-0002-6898-6887
Rolf RossaintDepartment of Anesthesiology, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
Marian WalterMedical Information Technology, RWTH Aachen University, Pauwelsstraße 20, 52074 Aachen, Germany.ORCID 0000-0003-4137-5370
Thomas BreuerDepartment of Intensive Care and Intermediate Care, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
Christian BleilevensDepartment of Anesthesiology, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
RWTH Aachen University · DE

Funding

Deutsche Forschungsgemeinschaft BR-5308/3-1Deutsche Forschungsgemeinschaft LE 817/37-1Deutsche Forschungsgemeinschaft RO 2000/23-1
6 · The paper itself

Abstract

backgroundHemocompatibility of left ventricular assist devices is essential for preventing adverse events. In this study, we compared the hemocompatibility of an axial-flow (Sputnik) to a centrifugal-flow (HeartMate 3) pump.

methodsBoth pumps were integrated into identical in vitro test circuits, each filled with 75 mL heparinized human blood of the same donor. During each experiment (n = 7), the pumps were operated with equal flow for six hours. Blood sampling and analysis were performed on a regular schedule. The analytes were indicators of hemolysis, coagulation activation, platelet count and activation, as well as extracellular vesicles.

resultsSputnik induced higher hemolysis compared to the HeartMate 3 after 360 min. Furthermore, platelet activation was higher for Sputnik after 120 min onward. In the HeartMate 3 circuit, the platelet count was reduced within the first hour. Furthermore, Sputnik triggered a more pronounced increase in extracellular vesicles, a potential trigger for adverse events in left ventricular assist device application. Activation of coagulation showed a time-dependent increase, with no differences between both groups.

conclusionsThis experimental study confirms the hypothesis that axial-flow pumps may induce stronger hemolysis compared to centrifugal pumps, coming along with larger amounts of circulating extracellular vesicles and a stronger PLT activation.

Indexed as

coagulationextracellular vesiclesHeartMate 3hemocompatibilityhemolysisin vitro test circuitleft ventricular assist deviceplatelet activationSputnik

Identifiers

PMID35743501
PMCPMC9225365
OpenAlexW4283008405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.