Evidence map›Paper›PMID 35743291›Full record

ArticleInternational journal of molecular sciences2022

Safety of Special Waveform of Transcranial Electrical Stimulation (TES): In Vivo Assessment.

Muhammad Adeel, Chun-Ching Chen, Bor-Shing Lin, Hung-Chou Chen, Jian-Chiun Liou, Yu-Ting Li, Chih-Wei Peng

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. [Research progress on combined transcranial electromagnetic stimulation in clinical application in brain diseases].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Review
  2. Article
  3. Article
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  5. Neural Correlates and Molecular Mechanisms of Memory and Learning.International journal of molecular sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Muhammad AdeelSchool of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0002-3681-6453
Chun-Ching ChenDepartment of Interaction Design, College of Design, National Taipei University of Technology, Taipei 106, Taiwan.ORCID 0000-0002-4146-5678
Bor-Shing LinDepartment of Computer Science and Information Engineering, National Taipei University, New Taipei City 237, Taiwan.ORCID 0000-0003-0498-3190
Hung-Chou ChenDepartment of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0001-8510-7437
Jian-Chiun LiouSchool of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.
Yu-Ting LiTaiwan Instrument Research Institute, National Applied Research Laboratories, Hsinchu 30261, Taiwan.
Chih-Wei PengSchool of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0001-9744-4094
Taipei Medical University · TWNational Institutes of Applied Research · TWNational Taipei University · TWNational Taipei University of Technology · TWTaipei Medical University-Shuang Ho Hospital · TW

Funding

Ministry of Science and Technology Taiwan 110-2314-B-038-001, 110-2811-E-038-500-MY3, 110-2314-B-305-001, 109-2314-B-305-001, 109-2221-E-305-001-MY2, 109-2221-E-038-005-MY3, and 109-2314-B-038-132University System of Taipei Joint Research Program Taiwan USTP-NTUT-TMU-111-03
6 · The paper itself

Abstract

Intermittent theta burst (iTBS) powered by direct current stimulation (DCS) can safely be applied transcranially to induce neuroplasticity in the human and animal brain cortex. tDCS-iTBS is a special waveform that is used by very few studies, and its safety needs to be confirmed. Therefore, we aimed to evaluate the safety of tDCS-iTBS in an animal model after brain stimulations for 1 h and 4 weeks. Thirty-one Sprague Dawley rats were divided into two groups: (1) short-term stimulation for 1 h/session (sham, low, and high) and (2) long-term for 30 min, 3 sessions/week for 4 weeks (sham and high). The anodal stimulation applied over the primary motor cortex ranged from 2.5 to 4.5 mA/cm

Indexed as

Transcranial Direct Current StimulationAnimalsEvoked Potentials, MotorInterleukin-6Neuronal PlasticityRatsRats, Sprague-DawleyTranscranial Magnetic StimulationInterleukin-6current densitydurationelectrical stimulationfrequencyintermittent theta burst stimulation (iTBS)in vivoprimary cortexsafety parametersscalptranscranial direct current stimulation (tDCS)

Identifiers

PMID35743291
PMCPMC9224937
OpenAlexW4283267832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.