Evidence map›Paper›PMID 35743233›Full record

ArticleInternational journal of molecular sciences2022

DMT1 Protects Macrophages from

Manuel Grander, Alexander Hoffmann, Markus Seifert, Egon Demetz, Philipp Grubwieser, Christa Pfeifhofer-Obermair, David Haschka, Günter Weiss

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. mBio · 2026
    Article
  3. SLC11A2 withholds divalent metals fromProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Review
  6. SLC11A2 affects nutritional immunity in the gut epithelium.bioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. The Multifaceted Role of Macrophages in Biology and Diseases.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Article
  11. Frontiers in cellular and infection microbiology · 2024
    Article
  12. Review
  13. Article
  14. Review
  15. Nutrients · 2023
    Article
  16. Article
  17. Review
  18. Frontiers in microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Manuel GranderDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Alexander HoffmannDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-4032-1517
Markus SeifertDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Egon DemetzDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Philipp GrubwieserDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0001-6233-8910
Christa Pfeifhofer-ObermairDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.
David HaschkaDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Günter WeissDepartment of Internal Medicine II, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-0709-2158
Innsbruck Medical University · AT

Funding

Christian Doppler Research Association to G.W.FWF Austrian Science Fund I 3321intramural funding program of the Medical University Innsbruck for young scientists MUI-START 2021-01-001
6 · The paper itself

Abstract

Macrophages are at the center of innate pathogen control and iron recycling. Divalent metal transporter 1 (DMT1) is essential for the uptake of non-transferrin-bound iron (NTBI) into macrophages and for the transfer of transferrin-bound iron from the endosome to the cytoplasm. As the control of cellular iron trafficking is central for the control of infection with siderophilic pathogens such as

Indexed as

IronSalmonella InfectionsAnimalsCation Transport ProteinsLipocalin-2MacrophagesMiceSalmonella typhimuriumSolute Carrier Family 11, Member 2TransferrinCation Transport ProteinsIronLipocalin-2Solute Carrier Family 11, Member 2TransferrinDMT1ironlipocalin 2macrophagenutritional immunitySalmonella Typhimurium

Identifiers

PMID35743233
PMCPMC9223531
OpenAlexW4283074815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.