Evidence map›Paper›PMID 35743227›Full record

ArticleInternational journal of molecular sciences2022

Lipidomic Approaches to Study HDL Metabolism in Patients with Central Obesity Diagnosed with Metabolic Syndrome.

Gabriele Mocciaro, Simona D'Amore, Benjamin Jenkins, Richard Kay, Antonio Murgia, Luis Vicente Herrera-Marcos, Stefanie Neun, Alice P Sowton, Zoe Hall, Susana Alejandra Palma-Duran and 9 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Deciphering Acute Coronary Syndromes Pathobiology Through Proteomics.Journal of cardiovascular development and disease · 2025
    Review
  13. Observational
  14. Oxidised Apolipoprotein Peptidome Characterises Metabolic Dysfunction-Associated Steatotic Liver Disease.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Recent Analytical Methodologies in Lipid Analysis.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Gabriele MocciaroDepartment of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge CB2 1GA, UK.ORCID 0000-0001-5392-0909
Simona D'AmoreDepartment of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0002-5432-8808
Benjamin JenkinsWelcome Trust-MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.ORCID 0000-0003-0038-9709
Richard KayWelcome Trust-MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Antonio MurgiaDepartment of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge CB2 1GA, UK.
Luis Vicente Herrera-MarcosDepartment of Biochemistry and Molecular and Cellular Biology, Veterinary Faculty, University of Zaragoza, 50013 Zaragoza, Spain.ORCID 0000-0002-4665-9674
Stefanie NeunDepartment of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge CB2 1GA, UK.ORCID 0000-0002-2469-6984
Alice P SowtonDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.ORCID 0000-0002-3718-7783
Zoe HallDepartment of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge CB2 1GA, UK.
Susana Alejandra Palma-DuranBiomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.
Giuseppe PalascianoClinica Medica "A. Murri", "Aldo Moro" University of Bari, 70124 Bari, Italy.
Frank ReimannWelcome Trust-MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Andrew MurrayDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.ORCID 0000-0002-0929-9315
Patrizia SuppressaDepartment of Interdisciplinary Medicine, Clinica Medica "C. Frugoni", Aldo Moro University of Bari, 70124 Bari, Italy.
Carlo SabbàDepartment of Interdisciplinary Medicine, Clinica Medica "C. Frugoni", Aldo Moro University of Bari, 70124 Bari, Italy.
Antonio MoschettaDepartment of Interdisciplinary Medicine, Clinica Medica "C. Frugoni", Aldo Moro University of Bari, 70124 Bari, Italy.ORCID 0000-0003-2123-6074
Albert KoulmanWelcome Trust-MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.ORCID 0000-0001-9998-051X
Julian L GriffinDepartment of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge CB2 1GA, UK.
Michele VaccaDepartment of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge CB2 1GA, UK.
University of Cambridge · GBUniversity of Bari Aldo Moro · ITWellcome/MRC Institute of Metabolic Science · GBImperial College London · GBUniversidad de Zaragoza · ESUniversity of Aberdeen · GB

Funding

Medical Research Council Lipid Profiling and Signalling, MC UP A90 1006 & Lipid Dynamics and Regulation, MC PC 13030Medical Research Council MC_PC_13030Medical Research Council MC_UU_00014/3Medical Research Council MC_UU_12012/3Medical Research Council MC_UU_12012/5Medical Research Council MR/M009041/1Wellcome Trust (WT220271)
6 · The paper itself

Abstract

The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors characterised by central obesity, atherogenic dyslipidaemia, and changes in the circulating lipidome; the underlying mechanisms that lead to this lipid remodelling have only been partially elucidated. This study used an integrated "omics" approach (untargeted whole serum lipidomics, targeted proteomics, and lipoprotein lipidomics) to study lipoprotein remodelling and HDL composition in subjects with central obesity diagnosed with MetS (

Indexed as

Insulin ResistanceMetabolic SyndromeCholesterolCholesterol, HDLHumansLipidomicsLipoproteinsObesityObesity, AbdominalPhosphatidylcholinesPhosphatidylcholine-Sterol O-AcyltransferaseCholesterolCholesterol, HDLLipoproteinsPhosphatidylcholinesPhosphatidylcholine-Sterol O-AcyltransferaseLC-MSlecithin cholesterol acyltransferase (LCAT)lipidomicslipoprotein metabolismobesity

Identifiers

PMID35743227
PMCPMC9223701
OpenAlexW4283033787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.