Evidence map›Paper›PMID 35743186›Full record

ArticleInternational journal of molecular sciences2022

Kidney-Specific CAP1/Prss8-Deficient Mice Maintain ENaC-Mediated Sodium Balance through an Aldosterone Independent Pathway.

Elodie Ehret, Yannick Jäger, Chloé Sergi, Anne-Marie Mérillat, Thibaud Peyrollaz, Deepika Anand, Qing Wang, Fréderique Ino, Marc Maillard, Stephan Kellenberger and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Epithelial NaComprehensive Physiology · 2024
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Elodie EhretDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland.ORCID 0000-0003-0181-4893
Yannick JägerDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland.
Chloé SergiDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland.
Anne-Marie MérillatDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland.
Thibaud PeyrollazDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland.
Deepika AnandDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland.ORCID 0000-0002-7844-7051
Qing WangService of Nephrology, Department of Medicine, Lausanne University Hospital (CHUV), CH-1011 Lausanne, Switzerland.
Fréderique InoDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland.
Marc MaillardService of Nephrology, Department of Medicine, Lausanne University Hospital (CHUV), CH-1011 Lausanne, Switzerland.ORCID 0000-0001-6428-0046
Stephan KellenbergerDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland.ORCID 0000-0003-1755-6198
Ivan GautschiDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland.
Roman SzaboNational Institutes of Health, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.
Thomas H BuggeNational Institutes of Health, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.
Lotte K VogelDepartment of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.ORCID 0000-0001-9920-0982
Edith HummlerDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland.ORCID 0000-0002-3887-2715
Simona FrateschiDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, CH-1011 Lausanne, Switzerland.
University of Lausanne · CHFORS – Swiss Centre of Expertise in the Social Sciences · CHNational Institutes of Health · USMax Planck Institute for Heart and Lung Research · DEUniversity of Copenhagen · DK

Funding

Cell surface serine proteases in development, tissue repair, and malignancyZIADE000699 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI BUGGE, THOMAS H · 2009 to 2025
$34.1M
National Center of Competence in Research (NCCR) N-403-07-23Swiss National Science Foundation 31003A-182478/1, 31003A-163347
6 · The paper itself

Abstract

The serine protease prostasin (CAP1/Prss8, channel-activating protease-1) is a confirmed in vitro and in vivo activator of the epithelial sodium channel ENaC. To test whether proteolytic activity or CAP1/Prss8 abundance itself are required for ENaC activation in the kidney, we studied animals either hetero- or homozygous mutant at serine 238 (S238A;

Indexed as

AldosteroneSodiumAnimalsEpithelial Sodium ChannelsKidneyMiceOligopeptidesProstasinSerine EndopeptidasesAldosteroneCAP1-6DEpithelial Sodium ChannelsOligopeptidesProstasinSerine EndopeptidasesSodiumCAP1/Prss8ENaC activation

Identifiers

PMID35743186
PMCPMC9224322
OpenAlexW4283015898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.