Evidence map›Paper›PMID 35743080›Full record

ArticleInternational journal of molecular sciences2022

Kinase Activity of PAR1b, Which Mediates Nuclear Translocation of the BRCA1 Tumor Suppressor, Is Potentiated by Nucleic Acid-Mediated PAR1b Multimerization.

Hiroko Nishikawa, Priscillia Christiany, Takeru Hayashi, Hisashi Iizasa, Hironori Yoshiyama, Masanori Hatakeyama

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hiroko NishikawaDivision of Microbiology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Priscillia ChristianyDivision of Microbiology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Takeru HayashiDivision of Microbiology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.ORCID 0000-0002-7881-3103
Hisashi IizasaDepartment of Microbiology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.ORCID 0000-0002-9202-2666
Hironori YoshiyamaDepartment of Microbiology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.ORCID 0000-0001-7588-278X
Masanori HatakeyamaDivision of Microbiology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.ORCID 0000-0001-7517-2649
The University of Tokyo · JPShimane University · JPHokkaido University · JP

Funding

Japan Society for the Promotion of Science 16H06373, 21H04804, JP17K14986, JP19K07660
6 · The paper itself

Abstract

PAR1b is a cytoplasmic serine/threonine kinase that controls cell polarity and cell-cell interaction by regulating microtubule stability while mediating cytoplasmic-to-nuclear translocation of BRCA1. PAR1b is also a cellular target of the CagA protein of

Indexed as

Helicobacter InfectionsHelicobacter pyloriNucleic AcidsAntigens, BacterialBacterial ProteinsBRCA1 ProteinHumansPhosphorylationProtein Serine-Threonine KinasesRNAAntigens, BacterialBacterial ProteinsBRCA1 ProteinBRCA1 protein, humanNucleic AcidsProtein Serine-Threonine KinasesRNAEBERgastric cancerkinase activationmultimerizationnucleic acidsPAR1b

Identifiers

PMID35743080
PMCPMC9223676
OpenAlexW4282946054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.