ReviewInternational journal of molecular sciences2022
Current Mechanistic Understandings of Lymphedema and Lipedema: Tales of Fluid, Fat, and Fibrosis.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07787234 (Systemic Inflammatory Indices in Lipedema Compared With BMI-Matched Obesity), which is not on this map. Cited by 63 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Systemic Inflammatory Indices in Lipedema Compared With BMI-Matched Obesity: The Distinct Clinical Relevance of the C-Reactive Protein-to-Albumin Ratio
Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Animal Models of Lymphaticovenous Anastomosis: A Systematic Review of Current Evidence and Future Directions in Translational Research.Microsurgery · 2026Pooled it
- Effectiveness of physical therapy for lower limb lymphedema in gynecological cancer survivors: a systematic review of randomized controlled trials.Frontiers in oncology · 2026Pooled it
- Effects of monoglucosyl hesperidin on human lymphatic circulatory function: A randomized placebo-controlled, double-blind, crossover trial.Scientific reports · 2026Trial
- Lipoedema and Obesity Misclassification: A Phenotype Based Approach to Cardiometabolic Risk Beyond Body Mass Index.Clinical obesity · 2026Review
- Molecular Distinctions, Diagnosis, and Mechanism-Based Therapies in Lipedema and Obesity.Current issues in molecular biology · 2026Review
- A perforator-based adipocutaneous skin paddle derived from free muscle flap reconstruction as a hypothesis-generating human tissue model of early localized lymphatic insufficiency.Scientific reports · 2026Article
- Current Evidence-Based Clinical Nutritional Approaches in Lipedema: A Scoping Review.Nutrition reviews · 2026Article
- Sexual function and its associations with anxiety, depression, functionality, and quality of life in women with lipedema.Sexual medicine · 2026Article
- Finite Element Modeling of Lower Limb Lymphedema: Influence of Limb Morphology and Compression Garment Classes on Internal Pressure Distribution.Annals of biomedical engineering · 2026Article
- Tamoxifen attenuates postsurgical hindlimb swelling and soft-tissue fibrosis in a rat model of secondary lymphatic injury.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- GLP-1 Receptors Are Enriched in the Lymphatic Endothelium and Their Pharmacological Activation With Semaglutide Improves the Pumping Capacity of Lymphatic Vessels.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Postoperative Seroma in Lipedema Surgery: A Retrospective Analysis of 93 Cases from a Single Surgical Team.Aesthetic plastic surgery · 2026Observational
- Keratinocytes: A key player in skin immunity and their emerging roles in secondary lymphedema.JID innovations : skin science from molecules to population health · 2026Review
- Automatic lymphedema segmentation in T2-STIR MRI using an unsupervised clustering method.La Radiologia medica · 2026Article
- Article
- Lipedema and obesity: A narrative review and treatment protocol.JPRAS open · 2026Review
- Cutaneous Sensory Alterations After Lower Limb Liposuction for Lipedema: A Comparative Study with Aesthetic Liposuction Patients.Aesthetic plastic surgery · 2026Article
- Article
- Unraveling lipedema: comprehensive insights and the path to future discoveries.npj metabolic health and disease · 2026Review
- Exosomes derived from ADSCs suppress the fibrosis process of derma in secondary lymphedema.Scientific reports · 2026Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Lymphedema and lipedema are complex diseases. While the external presentation of swollen legs in lower-extremity lymphedema and lipedema appear similar, current mechanistic understandings of these diseases indicate unique aspects of their underlying pathophysiology. They share certain clinical features, such as fluid (edema), fat (adipose expansion), and fibrosis (extracellular matrix remodeling). Yet, these diverge on their time course and known molecular regulators of pathophysiology and genetics. This divergence likely indicates a unique route leading to interstitial fluid accumulation and subsequent inflammation in lymphedema versus lipedema. Identifying disease mechanisms that are causal and which are merely indicative of the condition is far more explored in lymphedema than in lipedema. In primary lymphedema, discoveries of genetic mutations link molecular markers to mechanisms of lymphatic disease. Much work remains in this area towards better risk assessment of secondary lymphedema and the hopeful discovery of validated genetic diagnostics for lipedema. The purpose of this review is to expose the distinct and shared (i) clinical criteria and symptomatology, (ii) molecular regulators and pathophysiology, and (iii) genetic markers of lymphedema and lipedema to help inform future research in this field.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.