Evidence map›Paper›PMID 35743046›Full record

ArticleInternational journal of molecular sciences2022

Modafinil Administration to Preadolescent Rat Impairs Non-Selective Attention, Frontal Cortex D

Valeska Cid-Jofré, Macarena Moreno, Ramón Sotomayor-Zárate, Gonzalo Cruz, Georgina M Renard

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Therapeutic effects ofFrontiers in pharmacology · 2025
    Article
  3. Modafinil, an atypical CNS stimulant?Advances in pharmacology (San Diego, Calif.) · 2024
    Article
  4. Modafinil Improves Autism-like Behavior in Rats by Reducing Neuroinflammation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Valeska Cid-JofréCentro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Obispo Umaña 050, Estación Central, Santiago 9160019, Chile.ORCID 0000-0003-2227-1023
Macarena MorenoCentro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Obispo Umaña 050, Estación Central, Santiago 9160019, Chile.
Ramón Sotomayor-ZárateLaboratorio de Neuroquímica y Neurofarmacología, Centro de Neurobiología y Fisiopatología Integrativa (CENFI), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Av. Gran Bretaña 1111, Playa Ancha, Valparaíso 2360102, Chile.ORCID 0000-0002-1239-5367
Gonzalo CruzLaboratorio de Alteraciones Reproductivas y Metabólicas, Centro de Neurobiología y Fisiopatología Integrativa (CENFI), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Av. Gran Bretaña 1111, Playa Ancha, Valparaíso 2360102, Chile.ORCID 0000-0002-1458-3599
Georgina M RenardCentro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Obispo Umaña 050, Estación Central, Santiago 9160019, Chile.ORCID 0000-0002-5439-7547
Universidad de Santiago de Chile · CLUniversity of Valparaíso · CL

Funding

Agencia Nacional de Investigación y Desarrollo 21171017Dirección de Investigación Científica y Tecnológica, Universidad de Santiago de Chile 022101RSSADIUV-CI 01/2006FONDECYT 120-1816
6 · The paper itself

Abstract

The misuse of psychostimulants is an increasing behavior among young people, highlighting in some countries the abuse of modafinil (MOD) as a neuropotentiator. However, several clinical trials are investigating MOD as an alternative pharmacological treatment for attentional deficit and hyperactivity disorder (ADHD) in children and adolescents. On the other hand, the early use of psychostimulants and the misdiagnosis rates in ADHD make it crucial to investigate the brain effects of this type of drug in young healthy individuals. The aim of this work was to evaluate the effects of chronic MOD treatment on neurochemicals (γ-aminobutyric acid and glutamate), dopamine receptor 2 (D

Indexed as

Central Nervous System StimulantsVentral Tegmental AreaAdolescentAnimalsAttentiongamma-Aminobutyric AcidGlutamic AcidHumansMaleModafinilNucleus AccumbensPrefrontal CortexRatsRats, Sprague-DawleyCentral Nervous System Stimulantsgamma-Aminobutyric AcidGlutamic AcidModafinilADHDGABAglutamatemodafinilNSAnucleus accumbensprefrontal cortexpsychostimulantsventral tegmental area

Identifiers

PMID35743046
PMCPMC9223864
OpenAlexW4282831930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.