Evidence map›Paper›PMID 35743015›Full record

ArticleInternational journal of molecular sciences2022

Bulge-Forming miRNases Cleave Oncogenic miRNAs at the Central Loop Region in a Sequence-Specific Manner.

Olga Patutina, Daria Chiglintseva, Bahareh Amirloo, David Clarke, Svetlana Gaponova, Valentin Vlassov, Elena Bichenkova, Marina Zenkova

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Olga PatutinaInstitute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev's Ave. 8, 630090 Novosibirsk, Russia.
Daria ChiglintsevaInstitute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev's Ave. 8, 630090 Novosibirsk, Russia.ORCID 0000-0002-4416-1012
Bahareh AmirlooFaculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Oxford Rd, Manchester M13 9PT, UK.
David ClarkeFaculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Oxford Rd, Manchester M13 9PT, UK.ORCID 0000-0002-2777-8846
Svetlana GaponovaInstitute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev's Ave. 8, 630090 Novosibirsk, Russia.ORCID 0000-0001-7767-7712
Valentin VlassovInstitute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev's Ave. 8, 630090 Novosibirsk, Russia.
Elena BichenkovaFaculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Oxford Rd, Manchester M13 9PT, UK.ORCID 0000-0002-8186-9757
Marina ZenkovaInstitute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev's Ave. 8, 630090 Novosibirsk, Russia.ORCID 0000-0003-4044-1049
Institute of Chemical Biology and Fundamental Medicine · RUUniversity of Manchester · GB

Funding

Biotechnology and Biological Sciences Research Council BB/K012622/1Engineering and Physical Sciences Research Council EP/E003400/1Engineering and Physical Sciences Research Council EP/G03737X/1Russian Science Foundation 19-14-00250Russian-State-funded budget project of ICBFM SB RAS 1210313000445
6 · The paper itself

Abstract

The selective degradation of disease-associated microRNA is promising for the development of new therapeutic approaches. In this study, we engineered a series of bulge-loop-forming oligonucleotides conjugated with catalytic peptide [(LeuArg)

Indexed as

MicroRNAsCarcinogenesisHumansNucleic Acid ConformationOligonucleotidesPeptidesMicroRNAsOligonucleotidesPeptidesartificial ribonucleaseshybridizationmicroRNAmiRNasespeptide–oligonucleotide conjugatesRNA cleavageRNase Hturnover

Identifiers

PMID35743015
PMCPMC9224474
OpenAlexW4282547223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.