Evidence map›Paper›PMID 35742960›Full record

ArticleInternational journal of molecular sciences2022

Use of PET Imaging to Assess the Efficacy of Thiethylperazine to Stimulate Cerebral MRP1 Transport Activity in Wild-Type and APP/PS1-21 Mice.

Michael Wölfl-Duchek, Severin Mairinger, Irene Hernández-Lozano, Thomas Filip, Viktoria Zoufal, Mathilde Löbsch, Johann Stanek, Claudia Kuntner, Thomas Wanek, Martin Bauer and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. First-in-human evaluation of 6-bromo-7-[European journal of nuclear medicine and molecular imaging · 2024
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 5 countries.

Michael Wölfl-DuchekDepartment of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Severin MairingerDepartment of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-5094-9351
Irene Hernández-LozanoDepartment of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-3700-7690
Thomas FilipPreclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, 2444 Seibersdorf, Austria.
Viktoria ZoufalPreclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, 2444 Seibersdorf, Austria.
Mathilde LöbschPreclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, 2444 Seibersdorf, Austria.
Johann StanekDepartment of Biomedical Imaging und Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Claudia KuntnerDepartment of Biomedical Imaging und Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-5988-1434
Thomas WanekDepartment of Biomedical Imaging und Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, 1090 Vienna, Austria.
Martin BauerDepartment of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-4818-1560
Jens PahnkeDepartment of Neuro-/Pathology, Oslo University Hospital (OUS), University of Oslo (UiO), 0424 Oslo, Norway.ORCID 0000-0001-7355-4213
Oliver LangerDepartment of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-4048-5781
Austrian Institute of Technology · ATMedical University of Vienna · ATOslo University Hospital · NO

Funding

Austrian Science Fund FWF I 1609
6 · The paper itself

Abstract

Multidrug resistance-associated protein 1 (MRP1, encoded by the

Indexed as

Alzheimer DiseaseThiethylperazineAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsATP-Binding Cassette, Sub-Family C ProteinsBrainDisease Models, AnimalMiceMice, TransgenicPositron-Emission TomographyPresenilin-1Amyloid beta-PeptidesAmyloid beta-Protein PrecursorATP-Binding Cassette, Sub-Family C Proteinsmultidrug resistance-associated protein 1Presenilin-1Thiethylperazine6-bromo-7-[11C]methylpurineAlzheimer’s diseaseamyloid-betabrainMRP1 stimulationPETthiethylperazine

Identifiers

PMID35742960
PMCPMC9224167
OpenAlexW4281624436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.