Evidence map›Paper›PMID 35742924›Full record

ReviewInternational journal of molecular sciences2022

Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage.

Eva Giralt-Steinhauer, Joan Jiménez-Balado, Isabel Fernández-Pérez, Lucía Rey Álvarez, Ana Rodríguez-Campello, Ángel Ois, Elisa Cuadrado-Godia, Jordi Jiménez-Conde, Jaume Roquer

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  12. Small-vessel disease in the brain.American heart journal plus : cardiology research and practice · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eva Giralt-SteinhauerNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, Spain.
Joan Jiménez-BaladoNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, Spain.
Isabel Fernández-PérezNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, Spain.ORCID 0000-0002-9949-1393
Lucía Rey ÁlvarezNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, Spain.
Ana Rodríguez-CampelloNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, Spain.ORCID 0000-0001-8621-1420
Ángel OisNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, Spain.ORCID 0000-0002-1375-5950
Elisa Cuadrado-GodiaNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, Spain.ORCID 0000-0002-9147-875X
Jordi Jiménez-CondeNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, Spain.
Jaume RoquerNeurovascular Research Group, Neurology Department, Hospital de Mar, 08003 Barcelona, Spain.ORCID 0000-0001-5992-2606

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as: lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.

Indexed as

Cerebral Amyloid AngiopathyHypertensionStrokeCerebral HemorrhageEpigenesis, GeneticHumansTreatment Outcomeepigeneticsgeneticsintracerebral hemorrhage

Identifiers

PMID35742924
PMCPMC9223468

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.