Evidence map›Paper›PMID 35742850›Full record

ArticleInternational journal of molecular sciences2022

Inactivation of Osteoblast PKC Signaling Reduces Cortical Bone Mass and Density and Aggravates Renal Osteodystrophy in Mice with Chronic Kidney Disease on High Phosphate Diet.

Ariane Zaloszyc, Philippe Choquet, Amira Sayeh, Maria Bartosova, Betti Schaefer, Ulrike Huegel, Gaëlle Aubertin-Kirch, Christopher Healy, François Severac, Sébastien Rizzo and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Ariane ZaloszycService de Pédiatrie 1, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, 67098 Strasbourg, France.
Philippe ChoquetImagerie Préclinique-UF6237, Pôle d'Imagerie, Hôpitaux Universitaires de Strasbourg, 67098 Strasbourg, France.
Amira SayehImagerie Préclinique-UF6237, Pôle d'Imagerie, Hôpitaux Universitaires de Strasbourg, 67098 Strasbourg, France.
Maria BartosovaCenter for Pediatric and Adolescent Medicine, Division of Pediatric Nephrology, University of Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-1127-3453
Betti SchaeferCenter for Pediatric and Adolescent Medicine, Division of Pediatric Nephrology, University of Heidelberg, 69120 Heidelberg, Germany.
Ulrike HuegelCenter for Pediatric and Adolescent Medicine, Division of Pediatric Nephrology, University of Heidelberg, 69120 Heidelberg, Germany.
Gaëlle Aubertin-KirchMedical Image Analysis Center (MIAC AG), 4051 Basel, Switzerland.
Christopher HealyDepartment of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, London SE1 9RT, UK.
François SeveracGroupe Méthodes en Recherche Clinique (GMRC), Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.ORCID 0000-0002-6611-1921
Sébastien RizzoINSERM, UMR 1033, Université de Lyon, 69372 Lyon, France.
Georges BoivinINSERM, UMR 1033, Université de Lyon, 69372 Lyon, France.
Franz SchaeferCenter for Pediatric and Adolescent Medicine, Division of Pediatric Nephrology, University of Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0001-7564-9937
Michel FischbachService de Pédiatrie 1, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, 67098 Strasbourg, France.
Justine BacchettaINSERM, UMR 1033, Université de Lyon, 69372 Lyon, France.ORCID 0000-0002-0578-2529
Seiamak BahramOMICARE, Centre de Recherche d'Immunologie et d'Hématologie, Fédération Hospitalo-Universitaire, 67085 Strasbourg, France.
Claus Peter SchmittCenter for Pediatric and Adolescent Medicine, Division of Pediatric Nephrology, University of Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-4487-3332
Heidelberg University · DEHôpitaux Universitaires de Strasbourg · FRUniversité Claude Bernard Lyon 1 · FRInserm · FRKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) frequently leads to hyperphosphatemia and hyperparathyroidism, mineral bone disorder (CKD-MBD), ectopic calcifications and cardiovascular mortality. PTH activates the osteoanabolic Gα

Indexed as

Bone DiseasesChronic Kidney Disease-Mineral and Bone DisorderRenal Insufficiency, ChronicAnimalsBone DensityCalciumCortical BoneMiceMice, KnockoutOsteoblastsParathyroid HormonePhosphatesSignal TransductionCalciumParathyroid HormonePhosphatesbone scintigraphybone μCTCKD-MBDparathyroid related disorderpreclinical studies

Identifiers

PMID35742850
PMCPMC9223847
OpenAlexW4281776837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.