Evidence map›Paper›PMID 35742839›Full record

ArticleInternational journal of molecular sciences2022

Metabolomic Profiling of Angiotensin-II-Induced Abdominal Aortic Aneurysm in Ldlr

Juan Manuel Chao de la Barca, Alexis Richard, Pauline Robert, Maroua Eid, Olivier Fouquet, Lydie Tessier, Céline Wetterwald, Justine Faure, Celine Fassot, Daniel Henrion and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Mechanisms of metabolic reprogramming in abdominal aortic aneurysm.Frontiers in cell and developmental biology · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Juan Manuel Chao de la BarcaUMR CNRS 6015-INSERM U1083, IRIS2, 3 rue Roger Amsler, 49100 Angers, France.
Alexis RichardUMR CNRS 6015-INSERM U1083, IRIS2, 3 rue Roger Amsler, 49100 Angers, France.
Pauline RobertUMR CNRS 6015-INSERM U1083, IRIS2, 3 rue Roger Amsler, 49100 Angers, France.
Maroua EidService de Chirurgie Cardiaque, Centre Hospitalier Universitaire (CHU), 49100 Angers, France.
Olivier FouquetService de Chirurgie Cardiaque, Centre Hospitalier Universitaire (CHU), 49100 Angers, France.
Lydie TessierService de Biochimie et Biologie Moléculaire, Centre Hospitalier Universitaire (CHU), 49000 Angers, France.
Céline WetterwaldService de Biochimie et Biologie Moléculaire, Centre Hospitalier Universitaire (CHU), 49000 Angers, France.
Justine FaureService de Biochimie et Biologie Moléculaire, Centre Hospitalier Universitaire (CHU), 49000 Angers, France.
Celine FassotUMR CNRS 6015-INSERM U1083, IRIS2, 3 rue Roger Amsler, 49100 Angers, France.
Daniel HenrionUMR CNRS 6015-INSERM U1083, IRIS2, 3 rue Roger Amsler, 49100 Angers, France.ORCID 0000-0003-1094-0285
Pascal ReynierUMR CNRS 6015-INSERM U1083, IRIS2, 3 rue Roger Amsler, 49100 Angers, France.ORCID 0000-0003-0802-4608
Laurent LoufraniUMR CNRS 6015-INSERM U1083, IRIS2, 3 rue Roger Amsler, 49100 Angers, France.ORCID 0000-0003-3397-2335
Centre National de la Recherche Scientifique · FRCentre Hospitalier Universitaire d'Angers · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aneurysm is the second-most common disease affecting the aorta worldwide after atherosclerosis. While several clinical metabolomic studies have been reported, no study has reported deep metabolomic phenotyping in experimental animal models of aortic aneurysm. We performed a targeted metabolomics study on the blood and aortas of an experimental mice model of aortic aneurysm generated by high-cholesterol diet and angiotensin II in Ldlr

Indexed as

Aortic Aneurysm, AbdominalHypercholesterolemiaHyperlipidemiasAngiotensin IIAnimalsAorta, AbdominalDisease Models, AnimalEnergy MetabolismGlutamineGlycineLipidsMetabolomicsMiceMice, Inbred C57BLNitric OxideReceptors, LDLAngiotensin IIGlutamineGlycineLipidsNitric OxideReceptors, LDLaneurysmaortablood flowhypertensionlipidomicsmetabolomics

Identifiers

PMID35742839
PMCPMC9223449
OpenAlexW4281735808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.