Evidence map›Paper›PMID 35742735›Full record

SynthesisInternational journal of environmental research and public health2022

Prevalence, Features and Degree of Association of Oral Lesions in COVID-19: A Systematic Review of Systematic Reviews.

Federica Di Spirito, Alfredo Iandolo, Alessandra Amato, Mario Caggiano, Annunziata Raimondo, Serena Lembo, Stefano Martina

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Oral Lesions Following Anti-SARS-CoV-2 Vaccination: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Viral Infections of the Oral Cavity in Children.Children (Basel, Switzerland) · 2023
    Article
  8. Article
  9. Article
  10. Antibiotics in Dentistry: A Narrative Review of the Evidence beyond the Myth.International journal of environmental research and public health · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Oral Mycobiome and COVID-19.Microorganisms · 2023
    Article
  16. Review
  17. Article
  18. Article
  19. Infection Control in Dental Practice during the COVID-19 Pandemic: What Is Changed?International journal of environmental research and public health · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Federica Di SpiritoDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy.ORCID 0000-0002-5458-6559
Alfredo IandoloDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy.
Alessandra AmatoDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy.
Mario CaggianoDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy.ORCID 0000-0003-3163-7170
Annunziata RaimondoDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy.ORCID 0000-0002-0849-715X
Serena LemboDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy.
Stefano MartinaDepartment of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy.ORCID 0000-0003-3877-1671
University of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regardless of rapidly emerging findings on oral lesions described in adult SARS-CoV-2-positive subjects, the evidence level remains quite low and rather contrasting; therefore, the present systematic review of systematic reviews primarily aims to point out the overall prevalence of diagnosed cases. Secondary aims are to estimate the degree of association between oral lesions and SARS-CoV-2 infection and to grade, based on the reported frequency, the primary oral lesions, with related clinical presentations and microscopic features, in relation to COVID-19 forms. A study protocol compliant with the PRISMA statement was developed. Twelve studies were included, reporting highly heterogeneous and incomplete findings, thus precluding a meta-analysis. Further studies should be conducted to assess the overall prevalence of cases diagnosed with oral lesions among adult SARS-CoV-2-positive subjects, especially considering novel viral variants, and to determine their degree of association with SARS-CoV-2 infection and COVID-19 forms. Moreover, the reported findings noticed the need to evaluate the putative role both of SARS-CoV-2 in oral lesions genesis and of periodontitis and periodontal microbiome in COVID-19 worsening and re-activations. Deeper insights into oral lesions in adult SARS-CoV-2-positive subjects could enhance the comprehension of illness pathogenesis, natural history and clinical presentation, thus improving the preparedness of health professionals in the inter-disciplinary management of COVID-19.

Indexed as

COVID-19AdultHumansPrevalenceSARS-CoV-2Systematic Reviews as Topiccoronavirus disease 2019COVID-19oral lesionsoral manifestationsSARS-CoV-2

Identifiers

PMID35742735
PMCPMC9224460
OpenAlexW4283075732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.