Evidence map›Paper›PMID 35742682›Full record

ArticleInternational journal of environmental research and public health2022

Transcription Factor AhR, Cytokines IL-6 and IL-22 in Subjects with and without Peri-Implantitis: A Case Control-Study.

Luis Ricardo Linard Martins, Kinga Grzech-Leśniak, Nidia Castro Dos Santos, Lina J Suárez, Gabriela Giro, Marta Ferreira Bastos, Jamil Awad Shibli

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In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Luis Ricardo Linard MartinsDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, Brazil.
Kinga Grzech-LeśniakLaser Laboratory at Dental Surgery Department, Medical University of Wroclaw, 50-425 Wroclaw, Poland.ORCID 0000-0002-5700-4577
Nidia Castro Dos SantosDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, Brazil.ORCID 0000-0003-2041-9426
Lina J SuárezDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, Brazil.ORCID 0000-0003-2696-3051
Gabriela GiroDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, Brazil.
Marta Ferreira BastosPrograma de Pós Graduação em Ciências do Envelhecimento, Universidade São Judas Tadeu, Rua Taquari, 546, Sao Paulo 03166-000, Brazil.
Jamil Awad ShibliDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, Brazil.ORCID 0000-0003-1971-0195
Guarulhos University · BRUniversidade São Judas Tadeu · BRUniversidad Nacional de Colombia · COUniversity of Wrocław · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peri-implantitis is a plaque-associated condition characterized by mucosal inflammation and subsequent progressive loss of supporting bone; it is caused by bacterial biofilm, but the host response triggered by bacterial stimulation promotes the release of cells and mediators that culminate in tissue destruction. The Aryl-hydrocarbon Receptor (AhR) is associated with IL-22 production by Th22 and Th17 CD4+ Th cells. The presence of IL-6 may promote the Th22 phenotype. The present case-control study evaluated the gene expression of AhR, IL-22, and IL-6 in the peri-implant tissues of healthy and peri-implantitis patients. Tissue biopsies were collected from thirty-five volunteers (15 healthy and 20 with peri-implantitis). A real-time PCR reaction was utilized to assess the AhR, IL-22, and IL-6 gene expression levels relative to the reference gene (GAPDH). The results were analyzed using the Mann-Whitney test with a significance level of 5%. Higher levels of gene expression of AhR and IL-6 were detected in peri-implantitis tissues. The IL-22 gene expression levels did not differ between groups. In conclusion, higher gene expression levels for AhR and IL-6 were detected in the soft tissues of peri-implantitis patients. IL-22 did not vary between conditions, which may indicate the loss of the immunomodulatory role of IL-22 in periimplantitis.

Indexed as

Peri-ImplantitisBasic Helix-Loop-Helix ProteinsCase-Control StudiesCytokinesHumansInterleukin-22Interleukin-6InterleukinsReceptors, Aryl HydrocarbonAHR protein, humanBasic Helix-Loop-Helix ProteinsCytokinesInterleukin-22Interleukin-6InterleukinsReceptors, Aryl Hydrocarbongene expressioninterleukin-22interleukin-6peri-implantitisTh22 lymphocytestranscription factor aryl-hydrocarbon receptor

Identifiers

PMID35742682
PMCPMC9224299
OpenAlexW4283068439

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.