Evidence map›Paper›PMID 35742625›Full record

ArticleInternational journal of environmental research and public health2022

Mediation Analyses of the Role of Apathy on Motoric Cognitive Outcomes.

Mirnova E Ceïde, Daniel Eguchi, Emmeline I Ayers, David W Lounsbury, Joe Verghese

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Diminished Social and Leisure Engagement in Community Dwelling-Older Adults with Apathy.International journal of environmental research and public health · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mirnova E CeïdeDivision of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0001-5143-0615
Daniel EguchiMedical Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Emmeline I AyersDivision of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
David W LounsburyDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Joe VergheseDivision of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Funding

The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center studyR01AG057548 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI VERGHESE, JOE · 2020 to 2024
$8.0M
Research Education CoreP30AG059303 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jennifer Jaie Manly · 2018 to 2026
$6.0M
Biological and neural mechanisms of fallsR01AG044007 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VERGHESE, JOE · 2013 to 2017
$3.5M
Central Control of Mobility in AgingR01AG036921 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HOLTZER, ROEE · 2011 to 2015
$3.3M
NIA NIH HHS P30 AG059303NIA NIH HHS P30AG059303NIA NIH HHS R01 AG036921NIA NIH HHS R01AG036921NIA NIH HHS R01 AG044007NIA NIH HHS R01 AG057548NIA NIH HHS R01AG057548NIA NIH HHS R01AGO44007
6 · The paper itself

Abstract

Recent literature indicates that apathy is associated with poor cognitive and functional outcomes in older adults, including motoric cognitive risk syndrome (MCR), a predementia syndrome. However, the underlying biological pathway is unknown. The objectives of this study were to (1) examine the cross-sectional associations between inflammatory cytokines (Interleukin 6 (IL-6) and C-Reactive Protein (CRP)) and apathy and (2) explore the direct and indirect relationships of apathy and motoric cognitive outcomes as it relates to important cognitive risk factors.

Indexed as

ApathyCognition DisordersCognitive DysfunctionAgedCognitionCross-Sectional StudiesHumansInterleukin-6Mediation AnalysisRisk FactorsInterleukin-6apathydepressiongaitinflammationmotoric cognitive risk syndromemultimorbidity

Identifiers

PMID35742625
PMCPMC9224534

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.