Evidence map›Paper›PMID 35742610›Full record

ArticleInternational journal of environmental research and public health2022

The Phenotype of Bone Turnover in Patients with Fragility Hip Fracture: Experience in a Fracture Liaison Service Population.

Carla Caffarelli, Nicola Mondanelli, Eduardo Crainz, Stefano Giannotti, Bruno Frediani, Stefano Gonnelli

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. A novel "7 sutures and 8 knots" surgical technique in reverse shoulder arthroplasty for proximal humeral fractures: tuberosity healing improves short-term clinical results.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2023
    Observational
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Carla CaffarelliDepartment of Medicine, Surgery and Neuroscience, Section of Internal Medicine, University of Siena, 53100 Siena, Italy.
Nicola MondanelliDepartment of Medicine, Surgery and Neurosciences, Section of Orthopedics and Traumatology, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-0684-4197
Eduardo CrainzDepartment of Orthopaedics and Traumatology, Section of Orthopedics and Traumatology, University Hospital of Siena, 53100 Siena, Italy.
Stefano GiannottiDepartment of Medicine, Surgery and Neurosciences, Section of Orthopedics and Traumatology, University of Siena, 53100 Siena, Italy.
Bruno FredianiDepartment of Medicine, Surgery and Neurosciences, Rheumatology Unit, University of Siena, 53100 Siena, Italy.
Stefano GonnelliDepartment of Medicine, Surgery and Neuroscience, Section of Internal Medicine, University of Siena, 53100 Siena, Italy.
University of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hip fragility fractures are becoming one of the main health care problems in countries with an aging population. This study aimed to evaluate the clinical characteristics and the usefulness of bone turnover markers in patients with a hip fracture. Methods: In a cohort of 363 patients (84.1 ± 9.2 years) with hip fractures we measured 25-hydroxyvitamin D (25OHD), bone alkaline phosphatase, type I collagen β carboxy telopeptide (βCTX), and parathyroid hormone (PTH). We recorded patients’ Charlson Comorbidity Index (CCI) and previous history of fragility fractures. Results: Vitamin D and PTH levels were inversely correlated (r = −024; p < 0.001). The prevalence of 25OHD deficiency was 57.8%, the PTH levels greater than 65 pg/mL was in 47.0 %, and in those who had βCTX values the upper limit was 61.8%. Moreover, 62% of patients with a fragility hip fracture had a history of a previous fracture. The 25OHD serum levels were inversely associated with CCI and a previous fragility fracture. On the contrary, PTH and βCTX serum levels showed a positive significant correlation with CCI and previous fragility fractures. Conclusion: This study confirmed the usefulness of a bone turnover markers assessment, along with the comorbidities and history of previous fragility fractures in order to better identify the risk of hip fracture.

Indexed as

Hip FracturesVitamin D DeficiencyAgedAged, 80 and overBone DensityBone RemodelingHumansParathyroid HormonePhenotypeVitamin DParathyroid HormoneVitamin DCharlson Comorbidity IndexFracture Liaison Servicehip fractureprevious fragility fracturePTHvitamin DβCTX

Identifiers

PMID35742610
PMCPMC9223564
OpenAlexW4283031899

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.