Evidence map›Paper›PMID 35741734›Full record

ArticleGenes2022

HLA Genotypes and Type 1 Diabetes and Its Relationship to Reported Race/Skin Color in Their Relatives: A Brazilian Multicenter Study.

Marília B Gomes, Luís C Porto, Dayse A Silva, Carlos A Negrato, Elizabeth João Pavin, Renan Montenegro Junior, Sergio A Dib, João S Felício, Deborah C Santos, Luiza H Muniz and 3 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Marília B GomesDiabetes Unit, Rio de Janeiro State University, Rio de Janeiro 20551-30, Brazil.
Luís C PortoHistocompatibility and Cryopreservation Laboratory, Rio de Janeiro State University, Rio de Janeiro 20950-003, Brazil.
Dayse A SilvaDNA Diagnostic Laboratory, Rio de Janeiro State University, Rio de Janeiro 20550-900, Brazil.ORCID 0000-0003-3805-2837
Carlos A NegratoMedical Doctor Program, University of São Paulo, Bauru 17012-230, Brazil.
Elizabeth João PavinEndocrinology Division, Internal Medicine Department, School of Medical Sciences, State University of Campinas, Campinas 13083-887, Brazil.
Renan Montenegro JuniorDepartment of Community Health, Federal University of Ceará, Fortaleza 60430-235, Brazil.ORCID 0000-0001-7287-8726
Sergio A DibDepartment of Medicine, Federal University of São Paulo, São Paulo 04023-062, Brazil.
João S FelícioEndocrinology Division, Federal University of Pará, Belém 66050-060, Brazil.
Deborah C SantosDiabetes Unit, Rio de Janeiro State University, Rio de Janeiro 20551-30, Brazil.ORCID 0000-0002-0412-3193
Luiza H MunizDiabetes Unit, Rio de Janeiro State University, Rio de Janeiro 20551-30, Brazil.
Rosângela RéaDepartment of Internal Medicine, Federal University of Paraná, Curitiba 80060-900, Brazil.
Rossana Sousa AzulayService of Endocrinology, University Hospital of the Federal University of Maranhão, São Luís 65020-070, Brazil.ORCID 0000-0002-6097-8145
Vandilson RodriguesResearch Group in Clinical and Molecular Endocrinology and Metabology, Federal University of Maranhão, São Luís 65080-805, Brazil.ORCID 0000-0002-6785-7864
Universidade do Estado do Rio de Janeiro · BRUniversidade Federal do Maranhão · BRUniversidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de São Paulo · BRUniversidade Federal do Ceará · BRUniversidade Federal do Pará · BRUniversidade Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to investigate the relationship between HLA alleles in patients with type 1 diabetes from an admixed population and the reported race/skin color of their relatives. This cross-sectional, multicenter study was conducted in public clinics in nine Brazilian cities and included 662 patients with type 1 diabetes and their relatives. Demographic data for patients and information on the race/skin color and birthplace of their relatives were obtained. Typing of the HLA-DRB1, -DQA1, and -DQB1 genes was performed. Most studied patients reported having a White relative (95.17%), and the most frequently observed allele among them was DRB1*03:01. Increased odds of presenting this allele were found only in those patients who reported having all White relatives. Considering that most of the patients reported having a White relative and that the most frequent observed allele was DRB1*03:01 (probably a European-derived allele), regardless of the race/skin color of their relatives, we conclude that the type 1 diabetes genotype comes probably from European, Caucasian ethnicity. However, future studies with other ancestry markers are needed to fill the knowledge gap regarding the genetic origin of the type 1 diabetes genotype in admixed populations such as the Brazilian.

Indexed as

Diabetes Mellitus, Type 1HLA-DQ AntigensBrazilCross-Sectional StudiesGenotypeHLA-DQ alpha-ChainsHLA-DQ beta-ChainsHLA-DRB1 ChainsHumansSkin PigmentationHLA-DQ alpha-ChainsHLA-DQ AntigensHLA-DQ beta-ChainsHLA-DRB1 ChainsethnicityHLArelativesreported race/skin colortype 1 diabetes

Identifiers

PMID35741734
PMCPMC9223352
OpenAlexW4281652855

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.