Evidence map›Paper›PMID 35741704›Full record

ArticleGenes2022

Insight from

Maureen Neitz, Melissa Wagner-Schuman, Jessica S Rowlan, James A Kuchenbecker, Jay Neitz

Open access · goldAbstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Childhood Myopia Part I: Contemporary Treatment Options.Investigative ophthalmology & visual science · 2025
    Review
  11. Review
  12. Optical and Visual Diet in Myopia.Investigative ophthalmology & visual science · 2025
    Review
  13. iPhone-based anomaloscope for accessible, accurate color vision testing.Journal of the Optical Society of America. A, Optics, image science, and vision · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maureen NeitzDepartment of Ophthalmology, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0002-5404-3343
Melissa Wagner-SchumanDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA.
Jessica S RowlanDepartment of Ophthalmology, University of Washington, Seattle, WA 98109, USA.
James A KuchenbeckerDepartment of Ophthalmology, University of Washington, Seattle, WA 98109, USA.
Jay NeitzDepartment of Ophthalmology, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0003-3877-6712
University of Washington · USUniversity of Illinois Chicago · US

Funding

Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI MAUREEN E NEITZ · 1985 to 2026
$23.5M
Role of a dual splicing and amino acid code in myopia, cone dysfunction and cone dystrophy associated with L/M opsin interchange mutationsR01EY028118 · NEI · UNIVERSITY OF WASHINGTON · PI NEITZ, MAUREEN E · 2018 to 2022
$2.2M
Myopia: the role of cone opsin mutations & glasses that control axial elongationR01EY021242 · NEI · UNIVERSITY OF WASHINGTON · PI NEITZ, JAY · 2011 to 2015
$2.0M
NEI NIH HHS P30 EY001730NEI NIH HHS R01 EY021242NEI NIH HHS R01 EY028118
6 · The paper itself

Abstract

Nearsightedness (myopia) is a global health problem of staggering proportions that has driven the hunt for environmental and genetic risk factors in hopes of gaining insight into the underlying mechanism and providing new avenues of intervention. Myopia is the dominant risk factor for leading causes of blindness, including myopic maculopathy and retinal detachment. The fundamental defect in myopia-an excessively elongated eyeball-causes blurry distance vision that is correctable with lenses or surgery, but the risk of blindness remains. Haplotypes of the long-wavelength and middle-wavelength cone opsin genes (

Indexed as

MyopiaBlindnessChildExonsHaplotypesHumansMaleRetinal Cone Photoreceptor CellsRod Opsinslong-wavelength opsinRod Opsinscone opsin genesexon skippingmyopia geneticssplicing mutationXq28

Identifiers

PMID35741704
PMCPMC9222437
OpenAlexW3124936159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.