Evidence map›Paper›PMID 35741627›Full record

ReviewBrain sciences2022

Effects of Sound Interventions on the Permeability of the Blood-Brain Barrier and Meningeal Lymphatic Clearance.

Sean Sachdeva, Sushmita Persaud, Milani Patel, Peyton Popard, Aaron Colverson, Sylvain Doré

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sean SachdevaDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Sushmita PersaudDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Milani PatelDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Peyton PopardDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Aaron ColversonMusicology/Ethnomusicology Program, School of Music, College of the Arts, University of Florida, Gainesville, FL 32603, USA.ORCID 0000-0001-8900-4961
Sylvain DoréDepartment of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-3771-5109

Funding

Regulation and Implication of Hemoglobin Clearance in Subarachnoid Hemorrhagic PatientsR21NS095166 · NINDS · UNIVERSITY OF FLORIDA · PI DORE, SYLVAIN · 2016 to 2017
$426k
CO therapeutic role and potential mechanism in TBIR21NS103036 · NINDS · UNIVERSITY OF FLORIDA · PI DORE, SYLVAIN · 2018 to 2019
$419k
Potential stroke therapeutic efficacy of FumET-CORM through the Nrf2 pathwayR21NS110008 · NINDS · UNIVERSITY OF FLORIDA · PI DORE, SYLVAIN · 2019 to 2019
$419k
Testing brain penetrant iron chelators and investigating putative clearance pathway in ICHR56NS116076 · NINDS · UNIVERSITY OF FLORIDA · PI DORE, SYLVAIN · 2020 to 2020
$381k
NIH HHS NS095166NIH HHS NS103036NIH HHS NS110008NIH HHS NS116076NINDS NIH HHS R21 NS095166NINDS NIH HHS R21 NS103036NINDS NIH HHS R21 NS110008NINDS NIH HHS R56 NS116076
6 · The paper itself

Abstract

The meningeal lymphatic, or glymphatic, system is receiving increasing attention from the scientific community. Recent work includes noninvasive techniques to demonstrate relationships between blood-brain barrier (BBB) activity and the glymphatic system in the human central nervous system. One potential technique is the use of music/sound to enhance BBB permeability regarding the movement of small molecules in and out of the brain. However, there is minimal knowledge regarding the methodical investigation(s) of the uses of music/sound on BBB permeability and glymphatic clearance and the outcomes of these investigation(s). This review contains evidence discussing relationships between music/sound, BBB permeability, and meningeal lymphatic clearance. An overview of the anatomy and physiology of the system is presented. We discuss the uses of music/sound to modulate brain and body functions, highlighting music's effects on mood and autonomic, cognitive, and neuronal function. We also propose implications for follow-up work. The results showed that music and sound interventions do, in fact, contribute to the opening of the BBB and subsequently increase the function of the meningeal lymphatic system. Evidence also suggests that music/sound has the ability to reduce the collateral effects of brain injuries. Unfortunately, music/sound is rarely used in the clinical setting as a medical intervention. Still, recent research shows the potential positive impacts that music/sound could have on various organ systems.

Indexed as

eliminationglymphatic systemmeningesmusicnoiseopening

Identifiers

PMID35741627
PMCPMC9221168

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.