Evidence map›Paper›PMID 35741587›Full record

ArticleBrain sciences2022

A Novel Classification Model for Lower-Grade Glioma Patients Based on Pyroptosis-Related Genes.

Yusheng Shen, Hao Chi, Ke Xu, Yandong Li, Xisheng Yin, Shi Chen, Qian Yang, Miao He, Guohua Zhu, Xiaosong Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Yusheng ShenDepartment of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Hao ChiClinical Medicine College, Southwest Medical University, Luzhou 646000, China.ORCID 0000-0002-5210-0770
Ke XuDepartment of Oncology, Chongqing General Hospital, Chongqing 401147, China.
Yandong LiDepartment of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Xisheng YinClinical Medicine College, Southwest Medical University, Luzhou 646000, China.
Shi ChenClinical Molecular Medicine Testing Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Qian YangClinical Molecular Medicine Testing Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Miao HeLaboratory Animal Center of Chongqing Medical University, Chongqing 400016, China.
Guohua ZhuDepartment of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Xiaosong LiClinical Molecular Medicine Testing Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.ORCID 0000-0001-5533-7995
The Affiliated Yongchuan Hospital of Chongqing Medical University · CNXinjiang Medical University · CNSouthwest Medical University · CNChongqing Medical University · CNFirst People's Hospital of Chongqing · CN

Funding

Chongqing Science and Health Joint Medical High-end Talent Project 2022GDRC012National Natural Science Foundation of China 81871653Natural Science Foundation of Chongqing cstc2020jcyj-msxmX0159, cstc2021jsyj-yzysbAX0018Science and Technology Research Program of Chongqing Municipal Education Commission KJZD-K202100402, KJQN201900449
6 · The paper itself

Abstract

Recent studies demonstrated that pyroptosis plays a crucial role in shaping the tumor-immune microenvironment. However, the influence of pyroptosis on lower-grade glioma regarding immunotherapy and targeted therapy is still unknown. This study analyzed the variations of 33 pyroptosis-related genes in lower-grade glioma and normal tissues. Our study found considerable genetic and expression alterations in heterogeneity among lower-grade gliomas and normal brain tissues. There are two pyroptosis phenotypes in lower-grade glioma, and they exhibited differences in cell infiltration characteristics and clinical characters. Then, a PyroScore model using the lasso-cox method was constructed to measure the level of pyroptosis in each patient. PyroScore can refine the lower-grade glioma patients with a stratified prognosis and a distinct tumor immune microenvironment. Pyscore may also be an effective factor in predicting potential therapeutic benefits. In silico analysis showed that patients with a lower PyroScore are expected to be more sensitive to targeted therapy and immunotherapy. These findings may enhance our understanding of pyroptosis in lower-grade glioma and might help optimize risk stratification for the survival and personalized management of lower-grade glioma patients.

Indexed as

immunotherapylower-grade gliomapyroptosistargeted therapy

Identifiers

PMID35741587
PMCPMC9221219
OpenAlexW4281664939

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.