Evidence map›Paper›PMID 35741268›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Metaplastic Matrix-Producing Carcinoma and Apocrine Lobular Carcinoma In Situ Associated with Microglandular Adenosis: A Unique Case Report.

Nektarios Koufopoulos, Dionysios Dimas, Foteini Antoniadou, Kyparissia Sitara, Dimitrios Balalis, Ioannis Boutas, Alina Roxana Gouloumis, Adamantia Kontogeorgi, Lubna Khaldi

Open access · goldAbstract readCase Reports
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Nektarios KoufopoulosSecond Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece.ORCID 0000-0001-9502-7916
Dionysios DimasBreast Unit, Athens Medical Center, Psychiko Clinic, 11525 Athens, Greece.
Foteini AntoniadouDepartment of Pathology, "Alexandra" General Hospital, 11528 Athens, Greece.
Kyparissia SitaraDepartment of Internal Medicine, "Elpis" General Hospital of Athens, 11522 Athens, Greece.
Dimitrios BalalisDepartment of Surgical Oncology, Saint Savvas Anticancer Hospital of Athens, 11522 Athens, Greece.
Ioannis BoutasBreast Unit, Rea Maternity Hospital, P. Faliro, 17564 Athens, Greece.
Alina Roxana GouloumisSecond Department of Pathology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece.
Adamantia KontogeorgiThird Department of Obstetrics and Gynecology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 15772 Athens, Greece.
Lubna KhaldiDepartment of Pathology, Saint Savvas Anticancer Hospital of Athens, 11522 Athens, Greece.ORCID 0000-0002-4189-5029
National and Kapodistrian University of Athens · GRSt Savas Hospital · GRAlexandra Hospital · GRAthens Medical Center · GRGeneral Hospital of Athens Elpis · GRLETO Maternity Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglandular adenosis is a non-lobulocentric haphazard proliferation of small round glands composed of a single layer of flat to cuboidal epithelial cells. The glandular structures lack a myoepithelial layer; however, they are surrounded by a basement membrane. Its clinical course is benign, when it is not associated with invasive carcinoma. In around 30% of cases, there is a gradual transition to atypical microglandular adenosis, carcinoma in situ, and invasive breast carcinoma of several different histologic subtypes, including an invasive carcinoma of no special type, metaplastic matrix-producing carcinoma, secretory carcinoma, metaplastic carcinoma with squamous differentiation, acinic cell carcinoma, spindle cell carcinoma, and adenoid cystic carcinoma. Recent molecular studies suggest that microglandular adenosis is a non-obligate precursor of triple-negative breast carcinomas. In this manuscript, we present a unique case of microglandular adenosis associated with metaplastic matrix-producing carcinoma and HER-2 neu oncoprotein positive pleomorphic lobular carcinoma in situ with apocrine differentiation in a 79-year-old patient.

Indexed as

atypical microglandular adenosisbreast carcinomaHER-2 positivelobular carcinoma in situmatrix-producing carcinomametaplastic carcinomamicroglandular adenosispleomorphic lobular carcinoma in situtriple negative

Identifiers

PMID35741268
PMCPMC9221961
OpenAlexW4282828873

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.