Evidence map›Paper›PMID 35741201›Full record

ArticleDiagnostics (Basel, Switzerland)2022

T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study.

Uwe Schütz, Thomas Martensen, Sebastian Kleiner, Jens Dreyhaupt, Martin Wegener, Hans-Joachim Wilke, Meinrad Beer

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Uwe SchützDepartment of Diagnostic and Interventional Radiology, University Hospital Ulm, 89081 Ulm, Germany.ORCID 0000-0002-6772-9272
Thomas MartensenDepartment of Diagnostic and Interventional Radiology, University Hospital Ulm, 89081 Ulm, Germany.
Sebastian KleinerDepartment of Nuclear Medicine, Technical University Munich, Klinikum Rechts der Isar, 81675 München, Germany.
Jens DreyhauptDepartment of Biometrics, University Hospital Ulm, 89081 Ulm, Germany.ORCID 0000-0001-8057-161X
Martin WegenerDepartment of Diagnostic and Interventional Radiology, University Hospital Ulm, 89081 Ulm, Germany.
Hans-Joachim WilkeTrauma Research Centre, Institute of Orthopaedic Research and Biomechanics, Ulm University, 89081 Ulm, Germany.
Meinrad BeerDepartment of Diagnostic and Interventional Radiology, University Hospital Ulm, 89081 Ulm, Germany.ORCID 0000-0001-7523-1979
University Hospital Ulm · DETUM Klinikum · DEUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study intends to establish a study protocol for the quantitative magnetic resonance imaging (qMRI) measurement of biochemical changes in knee cartilage induced by mechanical stress during alpine skiing with the implementation of new spring-loaded ski binding.

methodsThe MRI-knee-scans (T2*-mapping) of four skiers using a conventional and a spring-loaded ski binding system, alternately, were acquired before and after 1 h/4 h of exposure to alpine skiing. Intrachondral T2* analysis on 60 defined regions of interest in the femorotibial knee joint (FTJ) was conducted. Intra- and interobserver variability and relative changes in the cartilage T2* signal and thickness were calculated.

resultsA relevant decrease in the T2* time after 4 h of alpine skiing could be detected at the majority of measurement times. After overnight recovery, the T2* time increased above baseline. Although, the total T2* signal in the superficial cartilage layers was higher than that in the lower ones, no differences between the layers in the T2* changes could be detected. The central and posterior cartilage zones of the FTJ responded with a stronger T2* alteration than the anterior zones.

conclusionsFor the first time, a quantitative MRI study setting could be established to detect early knee cartilage reaction due to alpine skiing. Relevant changes in the T2* time and thus in the intrachondral collagen microstructure and the free water content were observed.

Indexed as

cartilagekneeMRIosteoarthritisskiT2-mapping

Identifiers

PMID35741201
PMCPMC9222057
OpenAlexW4281722033

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.