Evidence map›Paper›PMID 35741190›Full record

ArticleDiagnostics (Basel, Switzerland)2022

A Fluorescence-Based Competitive Antibody Binding Assay for Kynurenine, a Potential Biomarker of Kidney Transplant Failure.

Max Borgolte, Isabel Quint, Lars Kaiser, René Csuk, Hans-Peter Deigner

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 66% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Max BorgolteInstitute of Precision Medicine, Furtwangen University, Jakob-Kienzle Str. 17, 78054 Villingen-Schwenningen, Germany.ORCID 0000-0003-4658-0699
Isabel QuintInstitute of Precision Medicine, Furtwangen University, Jakob-Kienzle Str. 17, 78054 Villingen-Schwenningen, Germany.
Lars KaiserInstitute of Precision Medicine, Furtwangen University, Jakob-Kienzle Str. 17, 78054 Villingen-Schwenningen, Germany.ORCID 0000-0002-3268-3307
René CsukInstitute of Organic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes-Str. 2, 06120 Halle (Saale), Germany.ORCID 0000-0001-7911-290X
Hans-Peter DeignerInstitute of Precision Medicine, Furtwangen University, Jakob-Kienzle Str. 17, 78054 Villingen-Schwenningen, Germany.ORCID 0000-0002-7745-0152
Martin Luther University Halle-Wittenberg · DEFraunhofer-Gesellschaft · DEUniversity of Freiburg · DEUniversity of Tübingen · DE

Funding

Federal Ministry for Economic Affairs and Climate Action, Germany 20934 NMinistry of Economics, Labor and Housing Baden-Württemberg 35-4223.10/10
6 · The paper itself

Abstract

Kynurenine is a tryptophan metabolite linked to several inflammatory processes including transplant failure, a significant challenge in transplant medicine. The detection of small molecules such as kynurenine, however, is often complex and time consuming. Herein, we report the successful synthesis of a fluorescently labelled kynurenine derivative, showing proper fluorescence and anti-kynurenine antibody binding behavior in a magnetic bead immunoassay (MIA). The fluorescent kynurenine-rhodamine B conjugate shows a K

Indexed as

amino acidsbiomarkersfluorescencefluorescent probeskynureninerapid testingtransplant failuretransplant medicine

Identifiers

PMID35741190
PMCPMC9221851
OpenAlexW4281666381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.