Evidence map›Paper›PMID 35741175›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Oxidative Stress Markers in Cerebrospinal Fluid of Newly Diagnosed Multiple Sclerosis Patients and Their Link to Iron Deposition and Atrophy.

Andrea Burgetova, Petr Dusek, Tomas Uher, Manuela Vaneckova, Martin Vejrazka, Romana Burgetova, Dana Horakova, Barbora Srpova, Jan Krasensky, Lukas Lambert

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  14. Article
  15. Oxidative Stress Markers in Multiple Sclerosis.International journal of molecular sciences · 2024
    Review
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  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Andrea BurgetovaDepartment of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague, Czech Republic.ORCID 0000-0002-9975-2338
Petr DusekDepartment of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague, Czech Republic.
Tomas UherDepartment of Neurology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague, Czech Republic.ORCID 0000-0003-3160-9022
Manuela VaneckovaDepartment of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague, Czech Republic.
Martin VejrazkaInstitute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague, Czech Republic.
Romana BurgetovaDepartment of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague, Czech Republic.
Dana HorakovaDepartment of Neurology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague, Czech Republic.
Barbora SrpovaDepartment of Neurology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague, Czech Republic.ORCID 0000-0002-8092-6625
Jan KrasenskyDepartment of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague, Czech Republic.
Lukas LambertDepartment of Radiology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague, Czech Republic.ORCID 0000-0003-2299-4707
Charles University · CZ

Funding

Charles University in Prague Cooperatio, Medical Diagnostics and Basic Medical SciencesMinistry of Health of the Czech Republic MH CZ-DRO, General University Hospital in Prague - VFN, 00064165Ministry of Health of the Czech Republic NV18-08-00062Roche company n/A
6 · The paper itself

Abstract

Oxidative stress has been implied in cellular injury even in the early phases of multiple sclerosis (MS). In this study, we quantified levels of biomarkers of oxidative stress and antioxidant capacity in cerebrospinal fluid (CSF) in newly diagnosed MS patients and their associations with brain atrophy and iron deposits in the brain tissue. Consecutive treatment-naive adult MS patients (

Indexed as

cerebrospinal fluidmagnetic resonance imagingmultiple sclerosisneutrophil gelatinase-associated lipocalinoxidative stressperoxiredoxin

Identifiers

PMID35741175
PMCPMC9221788
OpenAlexW4281661684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.