Evidence map›Paper›PMID 35741166›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Patterns of Focal Amyloid Deposition Using

Sung-Eun Chung, Hyung-Ji Kim, Sungyang Jo, Sunju Lee, Yoojin Lee, Jee Hoon Roh, Jae-Hong Lee

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Voxel-based evaluation for [Quantitative imaging in medicine and surgery · 2024
    Article
  3. Impact of simulated reduced injected dose on the assessment of amyloid PET scans.European journal of nuclear medicine and molecular imaging · 2024
    Article
  4. Generation of ConventionalMedicina (Kaunas, Lithuania) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sung-Eun ChungDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Hyung-Ji KimDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.ORCID 0000-0002-9163-4927
Sungyang JoDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Sunju LeeDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Yoojin LeeDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Jee Hoon RohNeuroscience Institute, Korea University College of Medicine, Seoul 02852, Korea.
Jae-Hong LeeDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Ulsan College · KRKorea University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulation of aggregated amyloid-β (Aβ) in the brain is considered the first pathological event within the pathogenesis of Alzheimer's disease (AD). It is difficult to accurately identify the initial brain regions of Aβ accumulation due to the time-lag between the start of the pathophysiology and symptom onset. However, focal regional amyloid uptake on amyloid PET scans may provide insights into this. Hence, we aimed to evaluate the topographic distribution of amyloid deposition in patients with cognitive impairment and to identify the starting order of amyloid accumulation in the brain using conditional probability. We enrolled 58 patients composed of 9 normal cognition (NC), 32 mild cognitive impairment (MCI), and 17 dementia showing focal regional amyloid deposition corresponding to a brain amyloid plaque load (BAPL) score of 2 among those who visited the Memory Clinic of Asan Medical Center and underwent an

Indexed as

Alzheimer’s diseaseamyloid beta 42conditional probability

Identifiers

PMID35741166
PMCPMC9221882
OpenAlexW4281627936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.