ArticleDiagnostics (Basel, Switzerland)2022
Neonatal Sequential Organ Failure Assessment (nSOFA) Score within 72 Hours after Birth Reliably Predicts Mortality and Serious Morbidity in Very Preterm Infants.
Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Exploratory Hemodynamic and Hematologic Trajectories by Culture Status Among Neonates Evaluated for Infection.Children (Basel, Switzerland) · 2026Article
- Association between reticulocyte hemoglobin content (RetHe) and neurodevelopmental outcomes in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Hemodynamic Assessment in Newborn Infants With Sepsis: A Prospective Observational Study.Cureus · 2026Article
- A Novel Fixel-Based Approach for Resolving Neonatal White Matter Microstructure from Clinical Diffusion MRI.medRxiv : the preprint server for health sciences · 2026Article
- Neonatal Sepsis as Organ Dysfunction: Prognostic Accuracy and Clinical Utility of the nSOFA in the NICU-A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- A novel fixel-based approach for resolving neonatal white matter microstructure from clinical diffusion MRI.Frontiers in neuroscience · 2026Article
- Clinical utility of combined serum IL-6, PCT, and SAA assays for early diagnosis and severity stratification of neonatal sepsis.Frontiers in medicine · 2026Article
- nSOFA scores predict prolonged mechanical ventilation in neonatal respiratory distress syndrome: a retrospective cohort study.BMC pediatrics · 2025Article
- Comparison of nSOFA and RSS for predicting bronchopulmonary dysplasia in preterm infants: a retrospective cohort study.BMJ paediatrics open · 2025Article
- Utility of the neonatal and pediatric sequential organ failure assessment scores in critically ill term neonates.Frontiers in pediatrics · 2025Article
- Comparing nSOFA, CRIB-II, and SNAPPE-II for predicting mortality and short-term morbidities in preterm infants ≤32 weeks gestation.Annals of medicine · 2024Article
- A Global Assessment of Coagulation Profile and a Novel Insight into Adamts-13 Implication in Neonatal Sepsis.Biology · 2023Article
- Early Prediction of Mortality after Birth Asphyxia with the nSOFA.Journal of clinical medicine · 2023Article
- Use of an electronic medical record to optimize a neonatal sepsis score for mortality prediction.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
The aim of this study was to assess the applicability of the neonatal sequential organ failure assessment score (nSOFA) within 72 h after delivery as a predictor for mortality and adverse outcome in very preterm neonates. Inborn neonates <32 weeks of gestation were evaluated. The nSOFA scores were calculated from medical records in the first 72 h after birth and the peak value was used for analysis. Death or composite morbidity at hospital discharge defined the adverse outcome. Composite morbidity consisted of chronic lung disease, intraventricular haemorrhage ≥grade III, periventricular leukomalacia and necrotizing enterocolitis. Among 423 enrolled infants (median birth weight 1070 g, median gestational age 29 weeks), 27 died and 91 developed composite morbidity. Death or composite morbidity was associated with organ dysfunction as assessed by nSOFA, systemic inflammatory response, and low birthweight. The score >2 was associated with OR 2.5 (CI 1.39−4.64, p = 0.002) for the adverse outcome. Area under the curve of ROC was 0.795 (95% CI = 0.763−0.827). The use of nSOFA seems to be reasonable for predicting mortality and morbidity in very preterm infants. It constitutes a suitable basis to measure the severity of organ dysfunction regardless of the cause.
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