Evidence map›Paper›PMID 35741078›Full record

ReviewCells2022

The Long Non-Coding RNA

Paul M Zakutansky, Yue Feng

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Genome-wide profiling of RNA 2'-bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. LncRNAs in modulating cancer cell resistance to paclitaxel (PTX) therapy.Medical oncology (Northwood, London, England) · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Paul M ZakutanskyGraduate Program in Biochemistry, Cell and Developmental Biology, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0001-6524-432X
Yue FengDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Emory University · US

Funding

Novel Regulation and Function of the lncRNA Gomafu in Human NeuronsR01NS110110 · NINDS · EMORY UNIVERSITY · PI FENG, YUE · 2019 to 2023
$2.9M
Regulation and function of human neural circular RNAsR01NS118819 · NINDS · EMORY UNIVERSITY · PI FENG, YUE, YAO, BING · 2021 to 2025
$2.7M
Use of CRISPR/Cas9 to Treat Huntington DiseaseR33NS106120 · NINDS · EMORY UNIVERSITY · PI YAO, BING · 2021 to 2022
$778k
Functional Post-Transcriptional Interplay of the Nuclear RNA Gomafu During Human Neural Cell DevelopmentF31MH127915 · NIMH · EMORY UNIVERSITY · PI ZAKUTANSKY, PAUL MICHAEL · 2021 to 2023
$140k
NIMH NIH HHS F31 MH127915NINDS NIH HHS R01 NS110110NINDS NIH HHS R01 NS118819NINDS NIH HHS R33 NS106120
6 · The paper itself

Abstract

Neuropsychiatric diseases are among the most common brain developmental disorders, represented by schizophrenia (SZ). The complex multifactorial etiology of SZ remains poorly understood, which reflects genetic vulnerabilities and environmental risks that affect numerous genes and biological pathways. Besides the dysregulation of protein-coding genes, recent discoveries demonstrate that abnormalities associated with non-coding RNAs, including microRNAs and long non-coding RNAs (lncRNAs), also contribute to the pathogenesis of SZ. lncRNAs are an actively evolving family of non-coding RNAs that harbor greater than 200 nucleotides but do not encode for proteins. In general, lncRNA genes are poorly conserved. The large number of lncRNAs specifically expressed in the human brain, together with the genetic alterations and dysregulation of lncRNA genes in the SZ brain, suggests a critical role in normal cognitive function and the pathogenesis of neuropsychiatric diseases. A particular lncRNA of interest is

Indexed as

MicroRNAsRNA, Long NoncodingSchizophreniaHumansRNA-Binding ProteinsMicroRNAsRNA-Binding ProteinsRNA, Long Noncodinggenetic riskGOMAFUlong non-coding RNARNA-binding proteinsschizophrenia

Identifiers

PMID35741078
PMCPMC9221589
OpenAlexW4283010962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.