Evidence map›Paper›PMID 35741001›Full record

ReviewCells2022

Obesity: The Fat Tissue Disease Version of Cancer.

Besma Boubertakh, Cristoforo Silvestri, Vincenzo Di Marzo

Abstract readReview
In one paragraph

Review in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Secreted Protein Acidic and Rich in Cysteine (Diseases (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Besma BoubertakhCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Département of Médecine, Faculté de Médecine, Université Laval, Québec City, QC G1V 0A6, Canada.
Cristoforo SilvestriCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Département of Médecine, Faculté de Médecine, Université Laval, Québec City, QC G1V 0A6, Canada.ORCID 0000-0001-5635-1545
Vincenzo Di MarzoCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Département of Médecine, Faculté de Médecine, Université Laval, Québec City, QC G1V 0A6, Canada.ORCID 0000-0002-1490-3070

Funding

CIHR
6 · The paper itself

Abstract

Obesity is a disease with high potential for fatality. It perfectly fits the disease definition, as cancer does. This is because it damages body structure and functions, both mechanically and biologically, and alters physical, mental, and social health. In addition, it shares many common morbid characteristics with the most feared disease, cancer. For example, it is influenced by a sophisticated interaction between a person's genetics, the environment, and an increasing number of other backgrounds. Furthermore, it displays abnormal cell growth and proliferation events, only limited to white fat, resulting in adipose tissue taking up an increasing amount of space within the body. This occurs through fat "metastases" and via altered signaling that further aggravates the pathology of obesity by inducing ubiquitous dishomeostasis. These metastases can be made graver by angiogenesis, which might boost diseased tissue growth. More common features with cancer include its progressive escalation through different levels of severity and its possibility of re-onset after recovery. Despite all these similarities with cancer, obesity is substantially less agitating for most people. Thus, the ideas proposed herein could have utility to sensitize the public opinion about the hard reality of obesity. This is increasingly needed, as the obesity pandemic has waged a fierce war against our bodies and society in general, while there is still doubt about whether it is a real disease or not. Hence, raising public consciousness to properly face health issues is crucial to improving our health instead of gaining weight unhealthily. It is obviously illogical to fight cancer extremely seriously on the one hand and to consider dying with obesity as self-inflicted on the other. In fact, obesity merits a top position among the most lethal diseases besides cancer.

Indexed as

Adipose TissueNeoplasmsHumansObesityWeight Gainangiogenesiscancercell growthcell proliferationdiseasegut microbiomemetastasisobesityrecurrencewhite adipose tissue

Identifiers

PMID35741001
PMCPMC9221301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.