Evidence map›Paper›PMID 35740895›Full record

ArticleBiomolecules2022

Design, Synthesis and Characterization of [G10a]-Temporin SHa Dendrimers as Dual Inhibitors of Cancer and Pathogenic Microbes.

Arif Iftikhar Khan, Shahzad Nazir, Aaqib Ullah, Muhammad Nadeem Ul Haque, Rukesh Maharjan, Shabana U Simjee, Hamza Olleik, Elise Courvoisier-Dezord, Marc Maresca, Farzana Shaheen

Abstract read
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arif Iftikhar KhanThird World Center for Science and Technology, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Shahzad NazirThird World Center for Science and Technology, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Aaqib UllahThird World Center for Science and Technology, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Muhammad Nadeem Ul HaqueThird World Center for Science and Technology, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Rukesh MaharjanH. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.ORCID 0000-0002-7597-7364
Shabana U SimjeeH. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Hamza OlleikAix-Marseille Univ., CNRS, Centrale Marseille, iSm2, 13013 Marseille, France.ORCID 0000-0002-3995-2207
Elise Courvoisier-DezordAix-Marseille Univ., CNRS, Centrale Marseille, iSm2, 13013 Marseille, France.ORCID 0000-0002-4256-3528
Marc MarescaAix-Marseille Univ., CNRS, Centrale Marseille, iSm2, 13013 Marseille, France.ORCID 0000-0002-3585-4765
Farzana ShaheenThird World Center for Science and Technology, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.ORCID 0000-0003-0057-3960

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the technologies for peptide synthesis and development continue to mature, antimicrobial peptides (AMPs) are being widely studied as significant contributors in medicinal chemistry research. Furthermore, the advancement in the synthesis of dendrimers' design makes dendrimers wonderful nanostructures with distinguishing properties. This study foregrounds a temporin SHa analog, [G10a]-SHa, and its dendrimers as globular macromolecules possessing anticancer and antibacterial activities. These architectures of temporin SHa, named as [G10a]-SHa, its dendrimeric analogs [G10a]

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsDendrimersNeoplasmsAntimicrobial Cationic PeptidesCircular DichroismHumansAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntineoplastic AgentsDendrimerstemporinantibacterialanticancerantimicrobial peptideD-alaninedendrimerRink amide resintemporin SHa

Identifiers

PMID35740895
PMCPMC9221442

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.