ArticleChildren (Basel, Switzerland)2022
Diagnostic Values of Red Flags and a Clinical Prediction Score for Emergent Intracranial Lesions in Non-Traumatic Pediatric Headaches.
Article in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Headache in the paediatric population: the role of the ophthalmologist.Frontiers in pediatrics · 2025Article
- Pediatric Migraines: A Comprehensive Review and Perspectives on Diagnosis and Treatment.Oman medical journal · 2023Review
- Pediatric headache: a narrative review.Journal of Yeungnam medical science · 2022Article
- Nontraumatic headaches in the emergency department: identifying clinical associations and predictive warning signs of intracranial pathologies.Annals of Saudi medicineArticle
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6 authors at 1 institution in 1 country.
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Abstract
introductionDiagnosis of emergent intracranial lesions that require emergency treatment either medically or surgically in non-traumatic pediatric headaches is important. Red-flag signs and symptoms are commonly used as justification for neuroimaging; however, evidence on its diagnostic values is limited. The study aims to identify diagnostic values of red-flags and develop a clinical prediction score to help improve the diagnostic yield of neuroimaging.
methodsA retrospective review of 109 pediatric patients from 2006 to 2020 who presented with a non-traumatic headache was conducted. A clinical prediction score from red flags was developed using multivariate logistic regression. Discriminatory ability was examined using the area under the receiver operating characteristic curve.
resultsA total of 51 patients were diagnosed with emergent intracranial lesions. Four potential clinical red flag predictors were identified: (1) acute onset (less than 3 months), (2) altered conscious state, (3) focal motor abnormality, and (4) and ocular/pupillary abnormality or squint. A clinical prediction score was developed with good discriminatory properties (0.84).
conclusionsClinical predictor scores from these four red flags may play an important role in maximizing neuroimaging and proper management for pediatric patients with non-traumatic headaches. Future validation studies are needed and could guide referrals and optimize the use of neuroimaging for these patients.
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