Evidence map›Paper›PMID 35740780›Full record

ArticleChildren (Basel, Switzerland)2022

Automated Movement Analysis to Predict Cerebral Palsy in Very Preterm Infants: An Ambispective Cohort Study.

Kamini Raghuram, Silvia Orlandi, Paige Church, Maureen Luther, Alex Kiss, Vibhuti Shah

Open access · goldAbstract read
In one paragraph

Article in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Kamini RaghuramDivision of Neonatology, Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada.ORCID 0000-0003-1765-8549
Silvia OrlandiBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON M4G 1R8, Canada.ORCID 0000-0003-2733-8450
Paige ChurchDivision of Neonatology, Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada.
Maureen LutherNeonatology and Neonatal Follow-Up, Women and Babies Program, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.
Alex KissInstitute for Clinical Evaluative Sciences (ICES), Toronto, ON M4N 3M5, Canada.
Vibhuti ShahDivision of Neonatology, Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada.ORCID 0000-0001-8685-2447
Sunnybrook Health Science Centre · CAHolland Bloorview Kids Rehabilitation Hospital · CAInstitute for Clinical Evaluative Sciences · CAMount Sinai Hospital · CAUniversity of Toronto · CA

Funding

Brain Canada Foundation n/aCIHR n/a
6 · The paper itself

Abstract

The General Movements Assessment requires extensive training. As an alternative, a novel automated movement analysis was developed and validated in preterm infants. Infants < 31 weeks’ gestational age or birthweight ≤ 1500 g evaluated at 3−5 months using the general movements assessment were included in this ambispective cohort study. The C-statistic, sensitivity, specificity, positive predictive value, and negative predictive value were calculated for a predictive model. A total of 252 participants were included. The median gestational age and birthweight were 274/7 weeks (range 256/7−292/7 weeks) and 960 g (range 769−1215 g), respectively. There were 29 cases of cerebral palsy (11.5%) at 18−24 months, the majority of which (n = 22) were from the retrospective cohort. Mean velocity in the vertical direction, median, standard deviation, and minimum quantity of motion constituted the multivariable model used to predict cerebral palsy. Sensitivity, specificity, positive, and negative predictive values were 55%, 80%, 26%, and 93%, respectively. C-statistic indicated good fit (C = 0.74). A cluster of four variables describing quantity of motion and variability of motion was able to predict cerebral palsy with high specificity and negative predictive value. This technology may be useful for screening purposes in very preterm infants; although, the technology likely requires further validation in preterm and high-risk term populations.

Indexed as

cerebral palsycomputer visionearly detectionearly interventiongeneral movements assessmentmachine learningneonatal follow-uppreterm infant

Identifiers

PMID35740780
PMCPMC9222200
OpenAlexW4283445680

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.