Evidence map›Paper›PMID 35740691›Full record

ReviewCancers2022

Target Definition in MR-Guided Adaptive Radiotherapy for Head and Neck Cancer.

Mischa de Ridder, Cornelis P J Raaijmakers, Frank A Pameijer, Remco de Bree, Floris C J Reinders, Patricia A H Doornaert, Chris H J Terhaard, Marielle E P Philippens

Abstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Magnetic Resonance Imaging Sequences and Technologies in Adaptive Radiation Therapy.International journal of radiation oncology, biology, physics · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mischa de RidderDepartment of Radiotherapy, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.ORCID 0000-0002-2530-3038
Cornelis P J RaaijmakersDepartment of Radiotherapy, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.
Frank A PameijerDepartment of Radiology, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.
Remco de BreeDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.ORCID 0000-0001-7128-5814
Floris C J ReindersDepartment of Radiotherapy, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.ORCID 0000-0002-1153-3625
Patricia A H DoornaertDepartment of Radiotherapy, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.
Chris H J TerhaardDepartment of Radiotherapy, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.
Marielle E P PhilippensDepartment of Radiotherapy, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, MRI-guided radiotherapy (MRgRT) has taken an increasingly important position in image-guided radiotherapy (IGRT). Magnetic resonance imaging (MRI) offers superior soft tissue contrast in anatomical imaging compared to computed tomography (CT), but also provides functional and dynamic information with selected sequences. Due to these benefits, in current clinical practice, MRI is already used for target delineation and response assessment in patients with head and neck squamous cell carcinoma (HNSCC). Because of the close proximity of target areas and radiosensitive organs at risk (OARs) during HNSCC treatment, MRgRT could provide a more accurate treatment in which OARs receive less radiation dose. With the introduction of several new radiotherapy techniques (i.e., adaptive MRgRT, proton therapy, adaptive cone beam computed tomography (CBCT) RT, (daily) adaptive radiotherapy ensures radiation dose is accurately delivered to the target areas. With the integration of a daily adaptive workflow, interfraction changes have become visible, which allows regular and fast adaptation of target areas. In proton therapy, adaptation is even more important in order to obtain high quality dosimetry, due to its susceptibility for density differences in relation to the range uncertainty of the protons. The question is which adaptations during radiotherapy treatment are oncology safe and at the same time provide better sparing of OARs. For an optimal use of all these new tools there is an urgent need for an update of the target definitions in case of adaptive treatment for HNSCC. This review will provide current state of evidence regarding adaptive target definition using MR during radiotherapy for HNSCC. Additionally, future perspectives for adaptive MR-guided radiotherapy will be discussed.

Indexed as

adaptive radiotherapydiffusion-weighted imaginghead and neck cancerIGRTMR-guided radiotherapyMRIoropharyngeal cancer

Identifiers

PMID35740691
PMCPMC9220977

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.