Evidence map›Paper›PMID 35740634›Full record

ArticleCancers2022

Is the Efficacy of Adding Ramucirumab to Docetaxel Related to a History of Immune Checkpoint Inhibitors in the Real-World Clinical Practice?

Tadashi Nishimura, Hajime Fujimoto, Tomohito Okano, Masahiro Naito, Chikashi Tsuji, Soichi Iwanaka, Yasumasa Sakakura, Taro Yasuma, Corina N D'Alessandro-Gabazza, Yasuhiro Oomoto and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Tadashi NishimuraDepartment of Pulmonary Medicine, Mie Chuo Medical Center, Tsu City 514-1101, Japan.ORCID 0000-0002-1688-1602
Hajime FujimotoDepartment of Pulmonary and Critical Care Medicine, Graduate School of Medicine, Mie University, Tsu City 514-8507, Japan.
Tomohito OkanoDepartment of Pulmonary and Critical Care Medicine, Graduate School of Medicine, Mie University, Tsu City 514-8507, Japan.
Masahiro NaitoDepartment of Pulmonary Medicine, Mie Chuo Medical Center, Tsu City 514-1101, Japan.
Chikashi TsujiDepartment of Pulmonary Medicine, Mie Chuo Medical Center, Tsu City 514-1101, Japan.
Soichi IwanakaDepartment of Pulmonary Medicine, Mie Chuo Medical Center, Tsu City 514-1101, Japan.
Yasumasa SakakuraDepartment of Pulmonary Medicine, Mie Chuo Medical Center, Tsu City 514-1101, Japan.
Taro YasumaDepartment of Immunology, Graduate School of Medicine, Mie University, Tsu City 514-8507, Japan.
Corina N D'Alessandro-GabazzaDepartment of Immunology, Graduate School of Medicine, Mie University, Tsu City 514-8507, Japan.
Yasuhiro OomotoDepartment of Pulmonary Medicine, Mie Chuo Medical Center, Tsu City 514-1101, Japan.
Esteban C GabazzaDepartment of Immunology, Graduate School of Medicine, Mie University, Tsu City 514-8507, Japan.ORCID 0000-0001-5748-1499
Tetsu KobayashiDepartment of Pulmonary and Critical Care Medicine, Graduate School of Medicine, Mie University, Tsu City 514-8507, Japan.
Hidenori IbataDepartment of Pulmonary Medicine, Mie Chuo Medical Center, Tsu City 514-1101, Japan.
Mie University · JPMie Chuo Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reports on the efficacy of second-line treatment with cytotoxic agents after treatment with immune checkpoint inhibitors are limited. Here, we retrospectively evaluated patients in the real-world clinical practice treated with docetaxel or docetaxel plus ramucirumab. Ninety-three patients treated with docetaxel or docetaxel plus ramucirumab as a second- or later-line therapy were included. The patients were categorized into the following four treatment groups: docetaxel group (

Indexed as

docetaxelimmune checkpoint inhibitornon-small cell lung cancerramucirumabvascular endothelial growth factor

Identifiers

PMID35740634
PMCPMC9221111
OpenAlexW4283069919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.