Evidence map›Paper›PMID 35740553›Full record

ArticleCancers2022

Dose Profile Modulation of Proton Minibeam for Clinical Application.

Myeongsoo Kim, Ui-Jung Hwang, Kyeongyun Park, Dohyeon Kim, Hak Soo Kim, Sang Hyoun Choi, Jong Hwi Jeong, Dongho Shin, Se Byeong Lee, Joo-Young Kim and 6 more

Abstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Myeongsoo KimDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, Korea.
Ui-Jung HwangDepartment of Radiation Oncology, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Kyeongyun ParkDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, Korea.
Dohyeon KimDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, Korea.ORCID 0000-0003-2923-5148
Hak Soo KimDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, Korea.ORCID 0000-0001-8983-5423
Sang Hyoun ChoiDepartment of Radiation Oncology, Korea Cancer Center Hospital, Seoul 01812, Korea.ORCID 0000-0002-7763-9844
Jong Hwi JeongDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, Korea.
Dongho ShinDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, Korea.
Se Byeong LeeDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, Korea.
Joo-Young KimDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, Korea.
Tae Hyun KimDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, Korea.ORCID 0000-0001-8413-3385
Hye Jung BaekRadiological Science Branch, Research Institute, National Cancer Center, Goyang 10408, Korea.
Hojin KimDepartment of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03722, Korea.
Kihwan KimDepartment of Radiation Oncology, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Sang Soo KimRadiological Science Branch, Research Institute, National Cancer Center, Goyang 10408, Korea.ORCID 0000-0002-4079-2503
Young Kyung LimDepartment of Radiation Oncology, Proton Therapy Center, National Cancer Center, Goyang 10408, Korea.ORCID 0000-0002-4176-6518

Funding

National Cancer Center NCC-2010290 and NCC-3110370
6 · The paper itself

Abstract

The feasibility of proton minibeam radiation therapy (pMBRT) using a multislit collimator (MSC) and a scattering device was evaluated for clinical use at a clinical proton therapy facility. We fabricated, through Monte Carlo (MC) simulations, not only an MSC with a high peak-to-valley dose ratio (PVDR) at the entrance of the proton beam, to prevent radiation toxicity, but also a scattering device to modulate the PVDR in depth. The slit width and center-to-center distance of the diverging MSC were 2.5 mm and 5.0 mm at the large end, respectively, and its thickness and available field size were 100 mm and 76 × 77.5 mm

Indexed as

multislit collimatorpeak-to-valley dose ratioproton minibeam radiation therapyproton therapyscattererspatially fractionated radiation therapy

Identifiers

PMID35740553
PMCPMC9221247

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.