ArticleCancers2022
The Impact of Cancer-Related Fatigue on HRQOL in Survivors of Childhood Cancer: A DCCSS LATER Study.
Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Structural equation modeling to explore putative causal factors for chronic fatigue in childhood cancer survivors: a DCCSS LATER study.Journal of cancer survivorship : research and practice · 2026Article
- Fatigue after pediatric bone sarcoma: prevalence and associated factors in pediatric and adult patients and survivors after treatment.Journal of cancer survivorship : research and practice · 2026Article
- Biomarker-based profiling of fatigue in childhood cancer survivors: evidence for distinct inflammatory and glial-associated profiles.Brain, behavior, & immunity - health · 2025Article
- Sleep Disorders, Dysregulation of Circadian Rhythms, and Fatigue After Craniopharyngioma-A Narrative Review.Biomedicines · 2025Review
- Sleep quality and physical fitness as modifiable contributors of fatigue in childhood cancer survivors.Journal of cancer survivorship : research and practice · 2025Article
- Attention to cancer-related physical and mental fatigue: Breaking the vicious cycle.World journal of psychiatry · 2025Article
- Auditory complications among childhood cancer survivors and health-related quality of life: a PanCareLIFE study.Journal of cancer survivorship : research and practice · 2025Article
- Article
- Health-related quality of life among cancer survivors: pre-existing chronic conditions are to be given priority.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Chronic fatigue in childhood cancer survivors is associated with lifestyle and psychosocial factors; a DCCSS LATER study.ESMO open · 2023Article
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Authors and funding
22 authors at 9 institutions in 3 countries.
Funding
Abstract
backgroundEarly detection and management of late effects of treatment and their impact on health-related quality of life (HRQOL) has become a key goal of childhood cancer survivorship care. One of the most prevalent late effects is chronic fatigue (CF). The current study aimed to investigate the association between CF and HRQOL in a nationwide cohort of CCS.
methodsParticipants were included from the Dutch Childhood Cancer Survivor Study (DCCSS) LATER cohort, a nationwide cohort of CCS. Participants completed the Checklist Individual Strength (CIS) to indicate CF (CIS fatigue severity subscale ≥ 35 and duration of symptoms ≥6 months) and the Short Form-36 (SF-36) and TNO (Netherlands Organization for Applied Scientific Research) and AZL (Leiden University Medical Centre) Adult's Health-Related Quality of Life questionnaire (TAAQOL) as measures for HRQOL. Differences in mean HRQOL domain scores between CF and non-CF participants were investigated using independent samples
resultsA total of 1695 participants were included in the study. Mean HRQOL domain scores were significantly lower in participants with CF. In addition, CF was associated with impaired HRQOL on all of the domains (except physical functioning) with adjusted odds ratios ranging from 2.1 (95% CI 1.3-3.4; sexuality domain) to 30.4 (95% CI 16.4-56.2; vitality domain).
conclusionsCF is associated with impaired HRQOL, urging for the screening and regular monitoring of fatigue, and developing possible preventative programs and interventions.
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