Evidence map›Paper›PMID 35740458›Full record

ArticleBiomedicines2022

Sulfonamide-Derived Dithiocarbamate Gold(I) Complexes Induce the Apoptosis of Colon Cancer Cells by the Activation of Caspase 3 and Redox Imbalance.

Javier Quero, José Carlos Royo, Beatrice Fodor, María Concepción Gimeno, Jesús Osada, María Jesús Rodríguez-Yoldi, Elena Cerrada

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Javier QueroDepartamento de Farmacología y Fisiología y Medicina Legal y Forense, Unidad de Fisiología, Universidad de Zaragoza, 50013 Zaragoza, Spain.
José Carlos RoyoDepartamento de Farmacología y Fisiología y Medicina Legal y Forense, Unidad de Fisiología, Universidad de Zaragoza, 50013 Zaragoza, Spain.
Beatrice FodorDepartamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea-ISQCH, Universidad de Zaragoza, 50009 Zaragoza, Spain.
María Concepción GimenoDepartamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea-ISQCH, Universidad de Zaragoza, 50009 Zaragoza, Spain.ORCID 0000-0003-0553-0695
Jesús OsadaDepartamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 50013 Zaragoza, Spain.ORCID 0000-0002-8251-8457
María Jesús Rodríguez-YoldiDepartamento de Farmacología y Fisiología y Medicina Legal y Forense, Unidad de Fisiología, Universidad de Zaragoza, 50013 Zaragoza, Spain.ORCID 0000-0002-3595-7668
Elena CerradaDepartamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea-ISQCH, Universidad de Zaragoza, 50009 Zaragoza, Spain.ORCID 0000-0003-2457-3674
Universidad de Zaragoza · ES

Funding

CIBEROBN CB06/03/1012Gobierno de Aragón B16_20R and E07_20RMCIN-Agencia Estatal de Investigación Grants PID2019-104379RB-C21/AEI/10.13039/501100011033MCIN-Agencia Estatal de Investigación Grants PID2019-104915RBI00Red Multimetdrugs RED2018-102471-T/MCIN/AEI/10.13039/501100011033
6 · The paper itself

Abstract

Two new families of dithiocarbamate gold(I) complexes derived from benzenesulfonamide with phosphine or carbene as ancillary ligands have been synthesized and characterized. In the screening of their in vitro activity on human colon carcinoma cells (Caco-2), we found that the more lipophilic complexes-those with the phosphine PPh

Indexed as

carbonic anhydrasecolon cancerdithiocarbamategold(I)sulfonamidethioredoxin reductase

Identifiers

PMID35740458
PMCPMC9221018
OpenAlexW4283025742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.