ArticleBiomedicines2022
A Metabolomic Profiling of Intra-Uterine Growth Restriction in Placenta and Cord Blood Points to an Impairment of Lipid and Energetic Metabolism.
Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolomic signatures associated with fetal growth restriction and small for gestational age: a systematic review.Nature communications · 2024Pooled it
- Dietary fiber supplementation during late gestation affects steroidogenesis, antioxidant capacity, gut microbiota and placental metabolomics of Rongchang sows.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Steroidogenic compensation and lipid deficiency with enhanced NADThe FEBS journal · 2026Article
- Metabolomic profiling reveals key metabolic pathway alterations in monochorionic diamniotic twins with selective intrauterine growth restriction.BMC pregnancy and childbirth · 2026Article
- Meconium metabolomic profiling dysregulation and neonatal brain injury in selective fetal growth restriction.BMC pregnancy and childbirth · 2026Article
- The evolving pathophysiology of bronchopulmonary dysplasia.Physiological reviews · 2026Review
- Integrated multi-omics analysis to explore correlations among cord blood IGF-1 levels, metabolomic profiles, and meconium gut microbiota in small-for-gestational-age neonates.Frontiers in pediatrics · 2026Article
- The placental transcriptome serves as a mechanistic link between prenatal phthalate exposure and placental efficiency.Environment international · 2025Article
- Umbilical cord serum metabolomics identifies amino acid alterations associated with impaired linear growth in small for gestational age infants.Scientific reports · 2025Article
- Sexually dimorphic impact of prenatal hyperandrogenism on offspring growth trajectory in sheep.Scientific reports · 2025Article
- Intrauterine growth restriction, defined by an elevated brain-to-liver weight ratio, affects faecal microbiota composition and, to a lesser extent, plasma metabolome profile at different ages in pigs.Animal microbiome · 2025Article
- Could we detect intraventricular hemorrhage before it happens?Pediatric research · 2024Article
- New insights and potential biomarkers for intraventricular hemorrhage in extremely premature infant, case-control study.Pediatric research · 2024Article
- Uteroplacental insufficiency decreases leptin expression and impairs lung development in growth-restricted newborn rats.Pediatric research · 2024Article
- Maternal Acylcarnitine Disruption as a Potential Predictor of Preterm Birth in Primigravida: A Preliminary Investigation.Nutrients · 2024Article
- Janus kinase-signal transducer and activator of transcription signaling pathway in the ocular cells of rat fetuses exposed to maternal saturated fat ingestion.Revista da Associacao Medica Brasileira (1992) · 2024Article
- The supplementation of female dogs with live yeastFrontiers in nutrition · 2024Article
- Fatty Acid Metabolism Disruptions: A Subtle yet Critical Factor in Adverse Pregnancy Outcomes.International journal of biological sciences · 2024Review
- Sex-Specific Perturbation of Systemic Lipidomic Profile in Newborn Lambs Impacted by Prenatal Testosterone Excess.Endocrinology · 2023Article
- Proteomics and Metabolomics in Biomedicine.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) Background: Intrauterine growth restriction (IUGR) involves metabolic changes that may be responsible for an increased risk of metabolic and cardiovascular diseases in adulthood. Several metabolomic profiles have been reported in maternal blood and urine, amniotic fluid, cord blood and newborn urine, but the placenta has been poorly studied so far. (2) Methods: To decipher the origin of this metabolic reprogramming, we conducted a targeted metabolomics study replicated in two cohorts of placenta and one cohort of cord blood by measuring 188 metabolites by mass spectrometry. (3) Results: OPLS-DA multivariate analyses enabled clear discriminations between IUGR and controls, with good predictive capabilities and low overfitting in the two placental cohorts and in cord blood. A signature of 25 discriminating metabolites shared by both placental cohorts was identified. This signature points to sharp impairment of lipid and mitochondrial metabolism with an increased reliance on the creatine-phosphocreatine system by IUGR placentas. Increased placental insulin resistance and significant alteration of fatty acids oxidation, together with relatively higher phospholipase activity in IUGR placentas, were also highlighted. (4) Conclusions: Our results show a deep lipid and energetic remodeling in IUGR placentas that may have a lasting effect on the fetal metabolism.
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