Evidence map›Paper›PMID 35740377›Full record

ArticleBiomedicines2022

Hideki Takakura, Toshimasa Nakao, Takumi Narita, Mano Horinaka, Yukako Nakao-Ise, Tetsushi Yamamoto, Yosuke Iizumi, Motoki Watanabe, Yoshihiro Sowa, Keisuke Oda and 3 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Citrus limon-Derived Extracellular Vesicles Promote Hair Growth.Applied biochemistry and biotechnology · 2026
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  14. The effectiveness and potential regulatory mechanism ofFrontiers in cell and developmental biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Hideki TakakuraDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.ORCID 0000-0003-3552-6144
Toshimasa NakaoDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Takumi NaritaDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.ORCID 0000-0002-8939-4346
Mano HorinakaDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Yukako Nakao-IseDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Tetsushi YamamotoPathological and Biomolecule Analyses Laboratory, Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.
Yosuke IizumiDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Motoki WatanabeDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.ORCID 0000-0002-9499-1161
Yoshihiro SowaDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.ORCID 0000-0001-5531-9009
Keisuke OdaLaboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hiroshima International University, Hiroshima 737-0112, Japan.
Nobuhiro MoriLaboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hiroshima International University, Hiroshima 737-0112, Japan.
Toshiyuki SakaiDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Michihiro MutohDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Kyoto Prefectural University of Medicine · JPHiroshima International University · JPKindai University · JP

Funding

Japan Agency for Medical Research and Development 20ck0106556h0001
6 · The paper itself

Abstract

Edible plant-derived nanovesicles have been explored as effective materials for preventing colorectal cancer (CRC) incidence, dependent on gene status, as a K-Ras-activating mutation via the macropinocytosis pathway. Approximately 70% of CRC harbors the p53 mutation, which is strongly associated with a poor prognosis for CRC. However, it has not been revealed whether p53 inactivation activates the macropinocytosis pathway or not. In this study, we investigated parental cells, wild-type or null for p53 treated with

Indexed as

colorectal cancercolorectal cancer preventionedible plantmacropinocytosisnanovesiclesp53

Identifiers

PMID35740377
PMCPMC9219868
OpenAlexW4281969663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.