Evidence map›Paper›PMID 35740340›Full record

ArticleBiomedicines2022

Inhibitory Effectiveness in Delayed-Rectifier Potassium Current Caused by Vortioxetine, Known to Be a Novel Antidepressant.

Hung-Tsung Hsiao, Jeffrey Chi-Fei Wang, Sheng-Nan Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Evaluation of Small-Molecule Candidates as Modulators of M-Type KInternational journal of molecular sciences · 2025
    Review
  3. The involvement of KTranslational psychiatry · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hung-Tsung HsiaoDepartment of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City 70101, Taiwan.ORCID 0000-0003-0836-707X
Jeffrey Chi-Fei WangDepartment of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City 70101, Taiwan.
Sheng-Nan WuDepartment of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan.ORCID 0000-0002-5208-3253
National Cheng Kung University Hospital · TWNational Cheng Kung University · TW

Funding

Ministry of Science and Technology, Taiwan MOST-110-2320-B-006-028
6 · The paper itself

Abstract

Vortioxetine (VOR) is recognized to exert antidepressant actions. However, whether this drug modifies ionic currents in excitable cells remains unclear. The aim of this study was to explore the electrophysiological effects of VOR and other related compounds in pituitary GH

Indexed as

binding schemecumulative inhibitiondelayed-rectifier K+ currenterg-mediated K+ currentinactivation kineticsneuroblastoma cellpituitary cellserotonin reuptakevoltage-gated K+ currentvortioxetine (1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine)

Identifiers

PMID35740340
PMCPMC9220334
OpenAlexW4281953626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.