Evidence map›Paper›PMID 35740315›Full record

ArticleBiomedicines2022

Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules.

Sara S Rinne, Wen Yin, Anna Mestre Borras, Ayman Abouzayed, Charles Dahlsson Leitao, Anzhelika Vorobyeva, John Löfblom, Stefan Ståhl, Anna Orlova, Torbjörn Gräslund

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sara S RinneDepartment of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.ORCID 0000-0003-2141-3982
Wen YinDepartment of Protein Science, KTH Royal Institute of Technology, 114 17 Stockholm, Sweden.
Anna Mestre BorrasDepartment of Protein Science, KTH Royal Institute of Technology, 114 17 Stockholm, Sweden.
Ayman AbouzayedDepartment of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.
Charles Dahlsson LeitaoDepartment of Protein Science, KTH Royal Institute of Technology, 114 17 Stockholm, Sweden.
Anzhelika VorobyevaDepartment of Immunology, Genetics and Pathology, Uppsala University, 752 37 Uppsala, Sweden.ORCID 0000-0002-4778-3909
John LöfblomDepartment of Protein Science, KTH Royal Institute of Technology, 114 17 Stockholm, Sweden.ORCID 0000-0001-9423-0541
Stefan StåhlDepartment of Protein Science, KTH Royal Institute of Technology, 114 17 Stockholm, Sweden.
Anna OrlovaDepartment of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden.ORCID 0000-0001-6120-2683
Torbjörn GräslundDepartment of Protein Science, KTH Royal Institute of Technology, 114 17 Stockholm, Sweden.ORCID 0000-0002-5391-600X
KTH Royal Institute of Technology · SEUppsala University · SE

Funding

China Scholarship Council Personal scholarship for Wen YinKnut and Alice Wallenberg Foundation 2019.0341Swedish Cancer Society 19 0101 Pj 01 HSwedish Cancer Society 20 0815 PjFSwedish Cancer Society 20 0893 PjSwedish Cancer Society 20 1090 PjFSwedish Cancer Society 2020/181Swedish Cancer Society 21 1861 PjSwedish Research Council 2019-00986Swedish Research Council 2019-05115VINNOVA 2019/00104
6 · The paper itself

Abstract

Increasing evidence suggests that therapy targeting the human epidermal growth factor receptor 3 (HER3) could be a viable route for targeted cancer therapy. Here, we studied a novel drug conjugate, Z

Indexed as

affibody drug conjugate (AffiDC)affibody moleculealbumin binding domainBxPC-3DM1emtansinehuman epidermal growth factor receptor 3 (HER3)

Identifiers

PMID35740315
PMCPMC9219639
OpenAlexW4281716748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.