Evidence map›Paper›PMID 35740248›Full record

ArticleBiomedicines2022

Comparison of CD3e Antibody and CD3e-sZAP Immunotoxin Treatment in Mice Identifies sZAP as the Main Driver of Vascular Leakage.

Shihyoung Kim, Rajni Kant Shukla, Eunsoo Kim, Sophie G Cressman, Hannah Yu, Alice Baek, Hyewon Choi, Alan Kim, Amit Sharma, Zhirui Wang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. CD3e-immunotoxin spares CD62LFrontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Shihyoung KimDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-8846-2853
Rajni Kant ShuklaDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-5722-449X
Eunsoo KimDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Sophie G CressmanDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Hannah YuDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-5354-7622
Alice BaekDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Hyewon ChoiDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Alan KimDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Amit SharmaDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-3836-5617
Zhirui WangDepartment of Surgery, University of Colorado Denver Anschutz Medical Campus, Division of Plastic & Reconstructive Surgery, 12700 East 19th Avenue, Aurora, CO 80045, USA.
Christene A HuangDepartment of Surgery, University of Colorado Denver Anschutz Medical Campus, Division of Plastic & Reconstructive Surgery, 12700 East 19th Avenue, Aurora, CO 80045, USA.
John C ReneauDivision of Hematology, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-6838-2410
Prosper N BoyakaDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Namal P M LiyanageDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Sanggu KimDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
The Ohio State University · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Targeting myeloid cells for regulation of alum-based immunityR01AI145144 · NIAID · OHIO STATE UNIVERSITY · PI BOYAKA, PROSPER N · 2020 to 2024
$3.1M
On-site, high-fidelity target sequencing and absolute quantitation for HIV-1 surveillanceR01HG010318 · NHGRI · OHIO STATE UNIVERSITY · PI KIM, SANGGU · 2018 to 2021
$2.9M
Regulation of mucosal IgA and allergic inflammation by intestinal epithelial cellsR01DK101323 · NIDDK · OHIO STATE UNIVERSITY · PI BOYAKA, PROSPER N · 2015 to 2019
$1.7M
Short Trem Research Training for Veterinary StudentsT35OD010977 · OD · OHIO STATE UNIVERSITY · PI Christine A Petersen · 2012 to 2026
$1.1M
Defining a therapeutic threshold in HSPC gene therapy for HIV-1 diseaseR00HL116234 · NHLBI · OHIO STATE UNIVERSITY · PI KIM, SANGGU · 2016 to 2018
$747k
High-accuracy, long-range sequencing for HIV-1 genotypingR21HG010108 · NHGRI · OHIO STATE UNIVERSITY · PI KIM, SANGGU · 2018 to 2020
$624k
NHGRI NIH HHS R01 HG010318NHGRI NIH HHS R21 HG010108NHLBI NIH HHS R00 HL116234NIAID NIH HHS R01 AI145144NIDDK NIH HHS R01 DK101323NIH HHS NHGRI R01HG010318NIH HHS NHGRI R21HG010108NIH HHS NHLBI R00HL116234NIH HHS T35 OD010977
6 · The paper itself

Abstract

Anti-CD3-epsilon (CD3e) monoclonal antibodies (mAbs) and CD3e immunotoxins (ITs) are promising targeted therapy options for various T-cell disorders. Despite significant advances in mAb and IT engineering, vascular leakage syndrome (VLS) remains a major dose-limiting toxicity for ITs and has been poorly characterized for recent "engineered" mAbs. This study undertakes a direct comparison of non-mitogenic CD3e-mAb (145-2C11 with Fc-silent

Indexed as

CD3e immunotoxinCD3e monoclonal antibodyimmunotherapyintravascular stainingmouse modelpolymorphonuclear leukocytes (PMN)saporinsaporin–streptavidin (sZAP)T-cell depletionvascular leakage syndrome

Identifiers

PMID35740248
PMCPMC9220018
OpenAlexW4281476234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.